环状RNA在皮肤相关疾病及创面愈合中的研究进展

Research progress of circular RNA in cutaneous diseases and wound healing

环状RNA(circRNA)为一类具有连续共价闭环结构的新型非编码RNA(ncRNA),无3′及5′游离末端。其可作为微小RNA(miRNA)“分子海绵”调节转录或剪接,也可与RNA结合蛋白相互作用,在机体生理和病理过程中都起着关键作用。近来有研究表明,在与创面愈合相关的细胞(血管内皮细胞、角质细胞)增殖、迁移等活动中,有circRNA参与其中。本文回顾了circRNA在不同类型皮肤细胞中发挥的调节作用及其与皮肤相关疾病如皮肤鳞状细胞癌、基底细胞癌、重度痤疮的联系,旨在为阐释创面愈合的细胞分子机制提供新思路,以期为解决临床上创面治疗难题开拓新方向。

Circular RNA(circRNA)is a novel class of non-coding RNA that assumes a covalently closed continuous loop without 3′and 5′free terminus.Some circRNA can serve as microRNA(miRNA)sponges,regulate transcription or splicing,and can interact with RNA binding proteins,thus playing pivotal roles in both physiological and pathological process.Recent studies suggest that circRNA has been involved in cellular activities like proliferation and migration of vascular endothelial cells and keratinocytes,which are associated with wound healing.This article reviewed the roles of circRNA in regulation of different types of skin cells,as well as its interaction with skin diseases like cutaneous squamous cell carcinoma,basal cell carcinoma and severe acne,with the purpose to propose new insights on the cellular and molecular mechanism of wound healing,and to exploit a novel direction in the solution to conundrums of clinical wound management.