计算机认知矫正治疗对抑郁症患者记忆功能的影响

Effect of computer cognitive remediation therapy on the memory of patients with depression

目的:探讨计算机认知矫正治疗(CCRT)改善抑郁症患者记忆功能的疗效。方法:100例于2017年5月至2018年12月在广西脑科医院就诊的抑郁症急性期发作的患者随机分成实验组和对照组各50例。实验组患者接受药物草酸艾司西酞普兰+CCRT治疗,对照组患者只接受草酸艾司西酞普兰治疗。分别在治疗前、治疗4周后进行威斯康星卡片分类测验(WCST)正确应答数百分比、临床记忆量表(CMS)的评估,评价两组患者治疗前后记忆功能的改善。之后实验组患者再继续接受2周的CCRT治疗,在治疗结束后进行威斯康星卡片分类测验(WCST)的正确应答数百分比、临床记忆量表(CMS)的评估,评价实验组患者治疗后记忆功能的继续改善。结果:治疗前两组患者在年龄、性别、文化程度、病程及WCST的正确应答数百分比和CMS各项指标方面比较,差异无统计学意义;与同组治疗前相比,两组患者治疗后WCST的正确应答数百分比和CMS各项指标均显著改善,差异均具有统计学意义(t=-4.379,-3.548,-4.996,-5.573,-4.640,-2.846,-2.914,-4.232,-5.507,-5.088,-10.364,-7.944,-5.301,-6.458;P<0.05);经治疗4周后,实验组患者WCS的正确应答数百分比和CMS各项评分指标显著优于对照组,差异均具有统计学意义(t=4.133,2.666,3.850,2.955,2.517,3.418,2.206;P<0.05);经治疗6周后,实验组患者WCS的正确应答数百分比和CMS各项评分指标与治疗4周后比较有显著改善,差异均具有统计学意义(t=-3.225,-2.764,-2.376,-3.119,-2.588,-3.276,-2.206;P<0.05)。结论:CCRT能改善抑郁症患者的记忆功能,而且治疗时间越长,效果越好。

Objective:To explore the effect of computer cognitive correction on memory function in patients with depression treated with(CCRT).Methods:A total of 100 patients with acute depression in Guangxi brain hospital from May 2017 to December 2018 were randomly divided into the experimental group(n=50)and the control group(n=50).The patients in the experimental group were treated with the drug escitalopram oxalate plus CCRT,while the patients in the control group were only treated with the drug escitalopram oxalate.The scores of correct response of Wisconsin card sorting test(WCST)and clinical memory scale(CMS)were assessed before treatment and 4 weeks after treatment,respectively,and the improvement of memory function of the two groups before and after treatment was evaluated.After that,the patients in the experimental group continued to receive CCRT treatment for 2 weeks.After the treatment,the correct response percentage of the Wisconsin card sorting test(WCST)and the clinical memory scale(CMS)were evaluated to evaluate the continuous improvement of the memory function of the patients in the experimental group after treatment.Results:There was no significant difference in age,sex,education level,course of disease,correct response percentage of WCST and various indexes of CMS between the two groups before treatment,but after treatment,the correct response percentage of WCST and the indexes of CMS in the two groups were significantly improved,and the difference was statistically significant(t=-4.379,-3.548,-4.996,-5.573,-4.640,-2.846,-2.914,-4.232,-5.507,-5.088,-10.364,-7.944,-5.301,-6.458;P<0.05).After 4 weeks of treatment,the correct response percentage of WCS and the scores of CMS in the experimental group were significantly better than those in the control group,and the differences were statistically significant(t=4.133,2.666,3.850,2.955,2.517,3.418,2.206;P<0.05).After 6 weeks of treatment,the correct response ratio of WCS and the scores of CMS in the experimental group were significantly improved compared with those after 4 weeks of treatment,and the differences were statistically significant(t=-3.225,-2.764,-2.376,-3.119,-2.588,-3.276,-2.206;P<0.05).Conclusion:CCRT can improve the memory function of patients with depression,and the longer the treatment time is,the better the effect is.