孕晚期生殖道B族链球菌定植对妊娠结局的影响

Effect of Group B Streptococcus Infection on Pregnancy Outcome

目的:分析孕晚期妇女生殖道B族链球菌定植情况,探讨B族链球菌定植对妊娠结局的影响及抗生素治疗效果。方法:选取2018年5月~2019年4月在北京市通州区中西医结合医院妇产科接受产前检查的295例妊娠35~37周的孕妇为研究对象,应用实时荧光定量PCR方法检测其生殖道B族链球菌,将结果呈阴性者纳入阴性组,并依据自愿原则将结果呈阳性的43例孕妇分为阳性A组(28例)和阳性B组(15例),对阳性A组给予抗生素治疗,阳性B组未接受抗生素治疗,观察并比较其妊娠结局。结果:比较不同年龄、产次、流产次数的孕晚期孕妇B族链球菌定植的阳性率,差异无统计学意义(P>0.05);阳性A组不良妊娠结局和围生儿不良结局发生率明显低于阳性B组,差异有统计学意义(P<0.05);阳性A组不良妊娠结局和围生儿不良结局与阴性组比较,差异有统计学意义(P<0.05)。结论:孕晚期生殖道B族链球菌定植会对妊娠结局造成不良影响,应用抗生素治疗可有效改善孕妇妊娠结局。

Objective:To analyze the colonization of group B Streptococcus in the reproductive tract of late pregnant women, and to explore the effect of group B Streptococcus colonization on pregnancy outcome and the effect of antibiotic treatment.Methods:A total of 295 pregnant women with 35~37 weeks of gestation who received prenatal examination in the Department of Gynecology and Obstetrics of Tongzhou District Hospital of Traditional Chinese and Western Medicine from May 2018 to April 2019 were selected as the research objects. Group B Streptococcus was detected by real time qPCR method in the reproductive tract of pregnant women. According to the colonization of group B Streptococcus, the negative results were included in the negative group, and the 43 pregnant women with positive results were divided into positive group according to the principle of voluntary group A of 25 cases and group B of 15 cases were treated with antibiotics, while group B was not treated with antibiotics.Results:There was no significant difference(P>0.05) in the positive rate of group B Streptococcus colonization among pregnant women of different ages, times of delivery and times of abortion. The incidence of adverse pregnancy outcome and perinatal outcome in positive group A was significantly lower than that in positive group B(P<0.05). There was significant difference between positive group A and negative group(P<0.05).Conclusion:The colonization of group B Streptococcus in the third trimester of pregnancy will cause adverse effects on the outcome of pregnancy.