早期CRRT在脓毒症治疗中的应用及疗效探究

The Application and Effect of Early CRRT in Treatment of Sepsis

目的:探讨早期CRRT在脓毒症治疗中的应用及疗效。方法:回顾性分析研究2015年1月-2019年1月笔者所在医院重症医学科收治的脓毒症患者80例。按治疗方式的不同分为常规治疗组(40例)及早期CRRT治疗组(40例),常规治疗组实施抗感染治疗及脏器支持治疗,早期CRRT治疗组则实施常规治疗+早期CRRT治疗。比较两组临床疗效、相关时间指标及治疗前后相关临床指标。结果:早期CRRT治疗组治疗总有效率高于常规治疗组,差异有统计学意义(P<0.05)。早期CRRT治疗组生命体征稳定时间、血清炎症指标恢复正常时间、低氧血症纠正时间、血流动力学稳定时间均短于常规治疗组,差异均有统计学意义(P<0.05)。治疗前两组血尿素氮、血小板计数、超敏C反应蛋白、血肌酐、急性生理与慢性健康评分比较差异无统计学意义(P>0.05),治疗后早期CRRT治疗组各指标均优于常规治疗组,差异均有统计学意义(P<0.05)。结论:常规治疗+早期CRRT治疗脓毒症效果确切,可有效控制机体炎症,稳定患者的生命体征,改善患者的健康状况。

Objective:To explore the application and efficacy of early CRRT in treatment of sepsis.Method:A retrospective analysis was performed on 80 sepsis patients admitted to the icu department of the author’s hospital from January 2015 to January 2019.According to different treatment methods,the patients were divided into the conventional group(40 cases)and the early CRRT treatment group(40 cases).The conventional group received anti-infection treatment and organ support treatment,while the early CRRT treatment group received routine treatment+early CRRT treatment.The two groups were compared in terms of clinical efficacy,related time indexes and related clinical indexes before and after treatment.Result:The total effective rate of the early CRRT treatment group was higher than that in the conventional group,the difference was statistically significant(P<0.05).The stabilization time of vital signs,serum inflammation index,hypoxemia correction time and hemodynamic stabilization time in the early CRRT group were shorter than those in the conventional group,the differences were statistically significant(P<0.05).There were no statistically significant differences in blood urea nitrogen,platelet count,hypersensitive C-reactive protein,serum creatinine,acute physiological and chronic health scores between the two groups before treatment(P>0.05),and all indicators of the early CRRT treatment group after treatment were better than those in the conventional group,the differences were statistically significant(P<0.05).Conclusion:Conventional therapy+early CRRT is effective in treating sepsis.It can effectively control the body’s inflammation,stabilize the vital signs of patients,and improve the health of patients.