不同锌制剂治疗小儿抗生素相关性腹泻及预防复发的效果对比观察

Comparative Observation of the Effect of Different Zinc Preparations in the Treatment of Antibiotic-associated Diarrhea and Prevention of Recurrence in Children

目的:探讨不同锌制剂治疗小儿抗生素相关性腹泻(AAD)及预防复发的效果。方法:选取笔者所在医院于2017年10月-2019年10月收诊的122例AAD患儿。按照等距抽样法将其分为对照组(61例)和观察组(61例)。对照组给予葡萄糖酸锌治疗,观察组给予锌硒制剂治疗。比较两组腹泻时间、呕吐时间、发热时间及腹泻复发率。结果:观察组腹泻时间(3.13±0.47)d,呕吐时间(1.79±0.35)d,发热时间(2.47±0.35)d,均短于对照组,差异有统计学意义(P<0.05)。观察组腹泻复发率为4.92%,低于对照组的18.03%,差异有统计学意义(P<0.05)。结论:应用锌硒制剂可改善AAD患儿临床症状,降低腹泻复发率,值得应用。

Objective:To explore the effect of different zinc preparations in the treatment of antibiotic-associated diarrhea(AAD)and prevention of recurrence in children.Method:A total of 122 children with AAD admitted in our hospital from October 2017 to October 2019 were selected.They were divided into the control group(61 cases)and the observation group(61 cases)by isometric sampling method.The control group was treated with Zzinc Gluconate,and the observation group was treated with Zinc Selenium Preparations.The diarrhea time,vomiting time,fever time and recurrence rate of diarrhea were compared between the two groups.Result:The diarrhea time(3.13±0.47)d,vomiting time(1.79±0.35)d,fever time(2.47±0.35)d in the observation group were all shorter than those in the control group,the differences were statistically significant(P<0.05).The recurrence rate of diarrhea in the observation group was 4.92%,which was lower than 18.03%in the control group,and the difference was statistically significant(P<0.05).Conclusion:The application of zinc selenium preparations can improve the clinical symptoms and reduce the recurrence rate of diarrhea in children with AAD,which is worthy of application.