血清sTREM-1、CD64、sCD163与脓毒症患者病情严重程度及预后的相关性

Correlation of Serum sTREM-1,CD64 and sCD163 with Severity and Prognosis of Sepsis

目的:探讨血清可溶性髓样细胞表达触发受体-1(sTREM-1)、中性粒细胞CD64、可溶性血红蛋白清道夫受体(sCD163)与脓毒症患者病情严重程度及预后的相关性。方法:选取笔者所在医院2018年1月-2019年12月收治的100例脓毒症患者,根据病情严重程度分为轻度组34例,严重组36例,休克组30例,并根据不同转归分为存活组和死亡组。统计不同病情程度及转归情况患者血清sTREM-1、CD64、sCD163水平,分析其与病情严重程度及预后的相关性。结果:休克组血清sTREM-1、CD64、sCD163水平均高于严重组及轻度组,且严重组血清sTREM-1、CD64、sCD163水平均高于轻度组,差异均有统计学意义(P<0.05);存活组血清sTREM-1、CD64、sCD163水平均低于死亡组,差异均有统计学意义(P<0.05);经Pearson相关性检验显示,血清sTREM-1、CD64、sCD163与脓毒症患者病情严重程度呈正相关(P<0.05),与预后呈负相关(P<0.05)。结论:血清sTREM-1、CD64、sCD163与脓毒症患者病情严重程度及预后关系密切,均可作为预测脓毒症患者病情严重程度及预后的参考指标。

Objective:To investigate the correlation between serum soluble myeloid cell expression trigger receptor-1(sTREM-1),neutrophil CD64,soluble hemoglobin scavenger receptor(sCD163)and severity and prognosis of patients with sepsis.Method:A total of 100 sepsis patients admitted to the author’s hospital from January 2018 to December 2019 were selected and divided into the mild group(34 cases),the severe group(36 cases)and the shock group(30 cases)according to the severity of the disease,and a survival group and a death group according to different outcomes,and they were divided into the survival group and the death group according to different outcomes.The serum streM-1,CD64 and sCD163 levels of patients with different disease degrees and outcomes were calculated,and the correlation between sTREM-1,CD64 and sCD163 levels and disease severity and prognosis were analyzed.Result:The serum streM-1,CD64 and sCD163 levels in the shock group were all higher than those in the severe group and the mild group,and serum sTREM-1,CD64 and sCD163 levels in the severe group were all higher than those in the mild group,the differences were statistically significant(P<0.05).The serum sTREM-1,CD64 and sCD163 levels in the survival group were all lower than those in the death group,the differences were statistically significant(P<0.05).Pearson correlation test showed that serum StreM-1,CD64,sCD163 were positively correlated with severity of sepsis patients(P<0.05),and negatively correlated with prognosis(P<0.05).Conclusion:Serum StreM-1,CD64 and sCD163 are closely related to the severity and prognosis of patients with sepsis,and can be used as reference indicators to predict the severity and prognosis of patients with sepsis.