新型冠状病毒肺炎患者外周血T淋巴细胞亚群分析

Analysis of T lymphocyte subsets in peripheral blood of patients with COVID-19

目的探讨新型冠状病毒肺炎患者外周血T淋巴细胞亚群的变化及其在病情分级中的作用。方法收集西安市胸科医院确诊的36例新型冠状病毒肺炎(COVID-19)患者的外周血T淋巴细胞亚群检测值,按普通组(轻型和普通型病例)与重症组(危、重型病例)、60岁及以上与60岁以下患者进行统计分析。结果36例COVID-19患者中总T淋巴细胞(CD3^+)计数减低发生率30.56%、T辅助淋巴细胞(CD4^+)计数减低发生率41.67%、淋巴细胞计数减低发生率50.00%、T抑制淋巴细胞(CD8^+)计数减低发生率5.56%。重症组CD3^+、CD4^+计数减低发生率高于普通组,差异有统计学意义(P<0.05);重症组CD3^+、CD8^+绝对计数低于普通组,差异有统计学意义(P<0.05)。60岁及以上患者CD3^+、CD8^+绝对计数低于60岁以下患者,差异有统计学意义(P<0.05)。结论新型冠状病毒肺炎患者外周血T淋巴细胞计数减低,尤以重症患者、60岁及以上患者显著。

Objective To explore the changes of T lymphocyte subsets in peripheral blood of patients with COVID-19 and their role in disease classification.Methods The clinical data of T lymphocyte subsets from 36 cases of COVID-19 diagnosed in Xi’an Chest Hospital were collected.The clinical data of T lymphocyte subsets were compared between ordinary group(light and ordinary cases)and severe group(dangerous and severe cases),and between≥60 years old group and<60 years old group.Results In 36 COVID-19 patients,the total incidence of decreased T lymphocyte count(CD3^+),decreased T helper lymphocyte count(CD4^+),decreased lymphocyte count and decreased T-suppressed lymphocyte(CD8^+)count was 30.56%,41.67%,50.00%and 5.56%respectively.The incidences of decreased CD3^+and CD4^+counts in severe group were significantly higher than those in ordinary group(P<0.05),and the absolute counts of CD3^+and CD8^+in severe group were lower than those in ordinary group.In addition,the absolute counts of CD3+and CD8+of patients over 60 years old were significant lower than those of patients under 60 years old(P<0.05).Conclusion T lymphocyte counts are decreased in COVID-19 patients,especially in critical patients and patients over 60 years old.