脱细胞基质材料与组织再生修复研究进展

The decellularized extracellular matrix in regenerative medicine

细胞外基质材料是通过组织或器官脱细胞化获得,其不仅能为再生的组织细胞提供三维支架结构,还具有调控再生细胞行为(包括细胞形态、黏附、增殖、迁移、分化及凋亡)、诱导干细胞增殖和分化及通过机械感知或受体介导调控细胞信号通路和基因表达等作用,也因其具有的这些良好的特性,近年来细胞外基质越来越广泛地被应用于组织再生修复中。该文通过广泛检索脱细胞基质材料用于组织再生修复的相关文献,对脱细胞基质材料促进组织再生修复中的作用及其应用进行分析总结。

Extracellular matrix material is obtained through decellularization of tissues or organs.It not only provides a 3D scaffold structure for regenerated tissue and cells,but also regulates the behavior of regenerated cells(including cell morphology,adhesion,proliferation,migration,differentiation and apoptosis).Induce stem cell proliferation and differentiation,and mediate cell signaling pathways and gene expression through mechanical sensing or receptor-mediated effects.Because of these good properties,extracellular matrix has been increasingly used in tissue regeneration in recent years.In this paper,the role and applications of acellular matrix materials in promoting tissue regeneration and reconstruction are analyzed and summarized.