血清超敏C-反应蛋白在儿童支气管哮喘合并过敏性鼻炎患者中的变化及临床意义

Changes and clinical significance of serum hs-CRP level in children with bronchial asthma combined with allergic rhinitis

目的探讨血清超敏C-反应蛋白(hs-CRP)在儿童支气管哮喘合并过敏性鼻炎患者中的变化及临床意义。方法选取单纯过敏性鼻炎(AR组)患儿100例、单纯性支气管哮喘(BA组)患儿100例及支气管哮喘合并过敏性鼻炎(BA+AR组)患儿100例,另选取同期至本院健康体检的儿童100例为对照组。比较4组血清hs-CRP水平的差异,分析血清hs-CRP水平与肺功能、IgE等指标的相关性。结果与对照组相比,AR组、BA组、BA+AR组IgE、血清hs-CRP水平、嗜酸性粒细胞计数、FeNO均显著升高,而FEV1占预计值百分比均显著降低,差异均有统计学意义(P <0.05);BA+AR组IgE、血清hs-CRP水平、嗜酸性粒细胞计数、Fe NO均显著高于AR组和BA组,而FEV1占预计值百分比显著低于AR组和BA组,差异均有统计学意义(P <0.05);Pearson相关分析提示,在支气管哮喘合并过敏性鼻炎患儿中,血清hs-CRP水平与IgE、嗜酸性粒细胞计数和FeNO呈正相关(r值分别为0.211、0.206、0.233,P <0.05),与FEV1占预计值百分比呈负相关(r=-0.242,P <0.001);Logistic回归分析提示,血清hs-CRP水平是支气管哮喘合并过敏性鼻炎的影响因素(P <0.05)。结论支气管哮喘合并过敏性鼻炎患儿血清hs-CRP水平明显升高,并且血清hs-CRP水平是支气管哮喘合并过敏性鼻炎的独立危险因素。

Objective To investigate the changes of serum hypersensitive C-reactive protein(hs-CRP)level and its clinical significance in children with bronchial asthma combined with allergic rhinitis.Methods A total of 100 children with allergic rhinitis(the AR group),100 children with bronchial asthma(the BA group),100 children with bronchial asthma combined with allergic rhinitis(the BA+AR group)and 100 healthy children were enrolled in our study.The differences of serum hs-CRP levels in the four groups were compared and the relationship between serum hs-CRP levels and clinical biomarkers was analyzed.Results Compared with the control group,children in the AR group,the BA group and the BA+AR group had higher IgE,serum hs-CRP levels,eosnophils counts and FeNO while lower FEV1%,with the differences statistically significant(P<0.05).Children in the BA+AR group had higher IgE,serum hs-CRP levels,eosnophils counts and FeNO while lower FEV1%than the BA group and the AR group,with the differences statistically significant(P<0.05).In children with BA+AR,serum hs-CRP level were significantly positive correlated with IgE,eosnophils counts,and FeNO(r=0.211,r=0.206,r=0.233,P<0.05),while significantly negative correlated with FEV1%(r=-0.242,P<0.001).Logistic analysis showed that serum hs-CRP level was an independent risk factor for the BA+AR(P<0.05).Conclusion Children in the BA+AR group has higher serum hs-CRP level which is an independent risk factor for the BA+AR.