长链非编码RNA与非酒精性脂肪性肝病

Long non-coding RNA and non-alcoholic fatty liver disease

LncRNA是由200多个核苷酸组成的转录产物,缺乏蛋白质编码能力。近年来lncRNAs已成为多种生物过程的重要调控因子,广泛参与了许多生物学过程,包括细胞分化、肿瘤发生、免疫反应、肝脏脂代谢和其他生物学过程。LncRNA可以调控多种基因表达,影响肝细胞内脂代谢,进而参与非酒精性脂肪性肝病的发生、发展,包括通过影响肝脏脂质合成、脂肪酸β氧化、通过microRNA调节某些靶点以及对肝脏基因的表观遗传调控来发挥作用。

LncRNA is a transcription product consisting of more than 200 nucleotides,which lacks the ability to encode proteins.In recent years,lncRNAs have become important regulators of various biological processes,and have been widely involved in many biological processes,including stem cell pluripotency,embryogenesis,cell differentiation,liver lipid metabolism and other biological processes.LncRNA can regulate the expression of a variety of genes and affect lipid metabolism in liver cells,and then participate in the development of non-alcoholic fatty liver disease.These include effects on liver lipid synthesis,fatty acid beta oxidation,regulation of certain targets by microRNA,and epigenetic regulation of liver genes.