环状RNA与脂代谢

Circular RNA and lipid metabolism

脂代谢参与了多种代谢相关疾病的发生、发展与调控,涉及营养调节、激素调节和体内平衡。近年来,越来越多的证据表明,非编码RNA的异常表达与代谢性疾病的发生和发展有关。其中,环状RNA作为一种新的非编码RNA,通过与相应的微小RNA或RNA结合蛋白相互作用,在脂代谢相关疾病如肥胖、2型糖尿病、动脉粥样硬化以及非酒精性脂肪性肝病等的发生、发展中起重要作用。

Lipid metabolism is a complex physical process including nutritional regulation,hormone regulation and homeostasis,which plays important roles in the occurrence and development of metabolic diseases.The past few decades have witnessed the progress made in exploring the potential role of noncoding RNA involved in metabolic diseases,especially for circular RNA(circRNA).Through interaction with microRNA or RNA binding protein,circRNA has a strong impact on lipid-related metabolic disorders including obesity,diabetes mellitus,cardiovascular diseases and non-alcoholic fatty liver disease.