基于新技术的糖尿病及其并发症动物模型研究进展

Research progress in models of diabetes and diabetic complications developed from new techniques

因糖尿病发病机制的复杂性和受累脏器的多样性,目前尚未见可完全复现人类糖尿病疾病进程的动物模型。传统糖尿病及其并发症动物模型缺乏统一的模型建立方法和成模标准,在模型诱导和表型方面存在一定局限性。应用基因编辑和遗传育种新技术构建的糖尿病及其并发症动物模型则克服了传统诱导方法的不足,具有较好的应用价值。选择合适的糖尿病及其并发症动物模型对研究结果的可靠性和研究结论的严谨性至关重要,有助于完善糖尿病发病机制理论和新的糖尿病治疗药物筛选。

Due to the complexity of the pathogenesis and the diversity of the affected organs,most of traditional animal models only possess some parts of metabolic phenotypes of diabetes.Considering the lack of uniform inducing protocol and modeling standards,there are shortcomings in the induction and phenotype among traditional models of diabetes and diabetic complications.Application of gene editing and genetic breeding to generate the models of diabetes and diabetic complications conquer some of the shortcomings mentioned above,which contains considerable application value.Therefore,it is crucial to choose appropriate animal models to ensure the reliability of research data and the conclusion.Furthermore,it may be helpful for understanding the pathogenesis of diabetes and contributing to the development of anti-diabetic drugs.