曲安奈德口腔软膏对轻型复发性阿弗他溃疡的临床疗效评估

Evaluation of clinical efficacy about triamcinolone acetonide oral ointment on minor recurrent aphthous ulcer

目的:研究曲安奈德口腔软膏局部治疗轻型复发性阿弗他溃疡(recurrent aphthous ulcer,RAU)的有效性。方法:选取2018年7月—2019年3月在南京医科大学附属口腔医院口腔黏膜科就诊的轻型RAU的患者,随机分为以下3组进行治疗:①曲安奈德口腔软膏联合口炎清颗粒(A组);②重组牛碱性成纤维细胞生长因子联合口炎清颗粒(B组);③桂林西瓜霜喷剂联合口炎清颗粒(C组)。分别记录用药前、用药第3、5、7 d 3组靶溃疡视觉类比量表(visual analog scale,VAS)值、面积大小、渗出、充血情况、愈合时间和止痛起效时间。结果:A组患者靶溃疡平均愈合时间和止痛起效时间均明显短于其余两组(P<0.05),同时,该组患者用药第3、7天靶溃疡的VAS评分改善值亦优于其余两组(P<0.05)。用药第3天时,A组患者靶溃疡面积改善值优于其余两组(P<0.05)。而A组的靶溃疡渗出及充血程度改善情况与其余两组相比,仅在第5天时差异有统计学意义(P<0.05)。结论:曲安奈德口腔软膏在治疗轻型RAU时有明显促进溃疡愈合及减轻患者疼痛的作用。

Objective:This study aims to evaluate the clinical efficacy about triamcinolone acetonide oral ointment on minor recurrent aphthous ulcer(RAU).Methods:Patients were selected from the Department of Oral Mucosal Disease,the Affiliated Stomatological Hospital of Nanjing Medical University from July 2018 to March 2019,and they were randomly divided into 3 groups.Group A was given with triamcinolone acetonide oral ointment and Kouyanqing granule;group B was treated with recombinant bovine basic fibroblast growth factor and Kouyanqing granule,group C was treated with Guilin watermelon frost spray and Kouyanqing granule.The scores of the visual analog scale(VAS)and the area and exudation as well as hyperemia of the target ulcer of patients were recorded at the first visit,the 3 rd,5 th and 7 th day of follow-up respectively.At the same time,the ulcer healing time and analgesic time were also recorded.Results:The average healing time and the analgesic time of group A were significantly shorter than that in other two groups(P<0.05).The average laxation score of VAS about the target ulcers on the 3 rd and 7 th day in group A was significantly higher than that in other two groups(P<0.05).On the third day,the reduced area of target ulcer of group A was significantly better than that of other two groups(P<0.05).At the same time,the exudation score and hyperemia score of group A were significantly different from the other two groups(P<0.05)only on the fifth day.Conclusion:Triamcinolone acetonide oral ointment has a significant effect on promoting ulcer healing and reducing pain of patients suffering in the treatment of minor recurrent aphthous ulcer.