IgA肾病遗传学机制进展

Advances in genetic mechanism of IgA nephropathy

IgA肾病(IgA nephropathy,IgAN)是一种免疫复合物介导的病因及致病机制不明的疾病。IgAN在全球各地均有报道,但其发生率具有明显种族及地域差异,此外部分IgAN患者呈现家族聚集起病,这些均提示遗传因素参与其致病。近年来,随着遗传学研究方法的不断改进,特别是全基因组关联分析研究(GWAS)在IgAN致病机制研究中的应用,增加人们对IgAN致病机制特别是遗传因素在致病机制中作用的认识,必将推动IgAN的预防、分子分型、预后评价、特异性治疗等方面的进展。文章将就IgAN近年来遗传学研究方面的进展展开综述。

As an immune complex-mediated disease with unknown etiology and pathogenic mechanism,IgA nephropathy(IgAN)has been reported all over the world.However,the incidence of IgAN has obvious ethnic and geographical differences.In addition,the onset of some patients has the characteristics of family aggregation. All of these suggest that genetic factors are involved in its pathogenesis.With the continuous improvement of genetic research methods,especially the applications of genome-wide association analysis(GWAS)in IgAN,the important roles of genetic factors in the pathogenic mechanism have been known. It will definitely promote the development of disease prevention,molecular typing,evaluation of prognosis and specific treatment. This article will review the advances in the genetic researches of IgAN in recent years.