2017年深圳市居民晚期糖基化终末产物膳食暴露水平概率评估

Exposure level of advanced glycation end products in the diet of Shenzhen residents in 2017

目的通过概率评估了解深圳市居民晚期糖基化终末产物(advanced glycation end products,AGEs)膳食暴露的水平。方法于2016年12月—2017年10月选择深圳市3家集贸市场、6家超市、10家连锁餐饮单位为采样点,分批采集了11类共196份食物样品,通过ELISA竞争法检测羧甲基赖氨酸得到AGEs含量数据库,结合2011年深圳市居民膳食与营养状况调查中的深圳居民食物消费量数据,通过蒙特卡洛模拟,应用拉丁超立方体法从AGEs含量数据和消费量数据中随机抽取数值计算AGEs膳食暴露量的概率分布,结果以不同百分位数所对应的暴露量(P50和P95)来表示。结果深圳市居民50%人群的人均AGEs膳食暴露量大于37.2 mg/d,而5%人群的人均AGEs膳食暴露量大于65.9 mg/d。对AGEs膳食暴露量影响最大的前3个因素为谷类及其制品AGEs含量(回归系数为0.61)、肉类及其制品AGEs含量(回归系数为0.44)、谷类及其制品消费量(回归系数为0.42)。P50和P95膳食AGEs暴露食物来源前3位均为谷类及其制品、调味品、肉类及其制品。结论2016—2017年5%深圳居民膳食AGEs摄入量偏大,AGEs主要来源为谷类及其制品、调味品和肉类及其制品。

OBJECTIVE To investigate the dietary exposure level of advanced glycation end products(AGEs)in the diet of Shenzhen residents.METHODS 3 markets,6 supermarkets and 10 chain catering units in Shenzhen were selected as sampling points.196 food samples were collected in 11 categories in batches from December 2016 to October 2017.The AGEs content database was obtained by detecting carboxy methyl lysine by ELISA competition method.Combined with the food consumption data of Shenzhen residents in the 2011 survey of dietary and nutritional status of Shenzhen residents,through Monte Carlo simulation,the probability distribution of AGEs dietary exposure was calculated by using the Latin hypercube method from the AGEs content data and consumption data,and the result were expressed by the exposure corresponding to different percentiles(P50 and P95).RESULTS In Shenzhen,50%of the population had a dietary exposure of more than 37. 2 mg /d per person,while 5% of the population had a dietary exposure of more than 65. 9 mg /d per person. The first three factors that had a great impact on the dietary exposure of AGEs were the AGEs content of cereal and its products,the AGEs content of meat and its products,and the consumption of cereal and its products. The top three sources of AGEs exposure for both P50 and P95 were cereal and its products and its products taste,meat and its products. CONCLUSION 5% of Shenzhen residents had a high intake of AGEs,which mainly came from cereals and their products,condiments,meat and their products.