加味麻杏石甘汤联合特布他林及布地奈德雾化吸入治疗小儿支气管哮喘急性发作临床研究

Clinical Study on Modified Maxing Shigan Tang Combined with Aerosol Inhalation of Terbutaline and Budesonide for Acute Attack of Bronchial Asthma in Children

目的:观察加味麻杏石甘汤联合特布他林及布地奈德雾化吸入治疗小儿支气管哮喘急性发作的临床疗效。方法:选取支气管哮喘急性发作患儿94例,按随机数字表法分为对照组和观察组各47例。对照组在常规治疗基础上给予特布他林及布地奈德雾化吸入治疗,观察组在对照组基础上给予加味麻杏石甘汤治疗。比较2组临床疗效和治疗前后肺功能指标,观察治疗期间不良反应发生情况。结果:观察组总有效率为97.87%,高于对照组85.11%,差异有统计学意义(P<0.05)。治疗前,2组第1秒用力呼气容积(FEV1)、呼气流量峰值(PEF)水平比较,差异无统计学意义(P>0.05)。治疗后,2组FEV1、PEF水平较治疗前升高(P<0.05),且观察组FEV1、PEF水平高于对照组(P<0.05)。治疗前,2组气喘、喉间哮鸣、咳嗽、咳痰各项症状积分比较,差异无统计学意义(P>0.05)。治疗后,2组气喘、喉间哮鸣、咳嗽、咳痰各项症状积分较治疗前降低(P<0.05),且观察组各项症状积分均低于对照组(P<0.05)。结论:加味麻杏石甘汤联合特布他林及布地奈德雾化吸入有助于改善支气管哮喘急性发作患儿肺功能和临床症状,疗效显著,且安全可靠。

Objective:To observe the clinical effect of modified Maxing Shigan tang combined with aerosol inhalation of terbutaline and budesonide for acute attack of bronchial asthma in children.Methods:A total of 94 cases of children with acute attack of bronchial asthma were divided into the control group and the observation group according to the random number table method,47 cases in each group.The control group was treated with aerosol inhalation of terbutaline and budesonide based on routine treatment,and the observation group was additionally treated with modified Maxing Shigan tang based on the treatment of the control group.The clinical effect and indexes of the lung function before and after treatment were compared between the two groups.The incidence of adverse reactions during treatment was observed.Results:After treatment,the total clinical effective rate was 97.78%in the observation group,higher than that of 85.11%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)between the two groups(P>0.05).After treatment,the levels of FEV1 and PEF in the two groups were increased when compared with those before treatment(P<0.05),and the above two levels in the observation group were higher than those in the control group(P<0.05).Before treatment,when compared the symptom scores of asthma,wheezing in the larynx,cough and expectoration between the two groups,there was no significance being found in the difference(P>0.05);after treatment,the above symptom scores in the two groups were all decreased when compared with those before treatment(P<0.05),and the scores in the observation group were all lower than those in the control group(P<0.05).Conclusion:The therapy of modified Maxing Shigan tang combined with aerosol inhalation of terbutaline and budesonide is conductive to improving the lung function and clinical symptoms in children with acute attack of bronchial asthma,with significant curative effect,safety and reliability.