不同剂量盐酸戊乙奎醚对患者术后认知的影响

Effect of Different Doses of Penehyclidine Hydrochloride on Postoperative Cognition

目的文章探讨不同剂量盐酸戊乙奎醚对患者术后认知功能的影响。方法随机选择手术患者作为研究对象,采取对照试验的方式来探讨不同剂量盐酸戊乙奎醚产生的效果。结果术后,对照组认知功能评分为(21.35±2.10)分,观察组为(26.17±2.60)分,观察组低于对照组(P <0.05)。对照组不良反应率为53.3%;观察组不良反应率达到26.7%。两组不良反应率差异有统计学意义(P <0.05);对照组中气道分泌物为(6.18±3.16)mL,观察组为(7.01±2.97)mL,两组比较差异无统计学意义(P> 0.05)。结论利用低剂量的盐酸戊乙奎醚来减轻认知功能障碍方法是安全可靠的,推荐在临床手术中使用该方法。

Objective To investigate the effects of different doses of penehyclidine hydrochloride on postoperative cognitive function in patients. Methods The patients who underwent surgery were randomLy selected as the research subjects. The effects of different doses of penehyclidine hydrochloride were investigated by means of controlled experiments. Results After operation, the cognitive function score of the control group was(21.35±2.10) points, and that of the observation group was(26.17±2.60) points. The observation group was significantly lower than the control group, P<0.05. The adverse reaction rate of the control group was 53.3%;the adverse reaction rate of the observation group was 26.7%. The adverse reaction rate was significantly different between the two groups(P<0.05). The airway secretion in the control group was(6.18±3.16) mL, and that in the observation group was(7.01±2.97) mL. There was no significant difference between the two groups(P>0.05). Conclusion The use of low doses of penehyclidine hydrochloride to alleviate cognitive dysfunction is safe and reliable. It is recommended to use this method in clinical surgery.