氨甲环酸的临床应用进展

The clinical application progress of tranexamic acid

氨甲环酸是一种人工合成的赖氨酸衍生物,可抑制纤溶酶的作用,从而显示出止血、抗变态反应、消炎效果,属于抗纤维蛋白溶解剂。近些年来氨甲环酸已经广泛应用于临床心脏手术、急性创伤出血以及产科出血,以减少术中出血并改善远期预后,其在临床使用中的风险效益比仍需关注。

Tranexamic acid is a synthetic lysine derivative that can inhibit the action of plasmin, thereby showing hemostatic, anti-allergic and anti-inflammatory effects, and belongs to an anti-fibrinolytic agent. In recent years, it has been widely used in clinical cardiac surgery, acute traumatic bleeding, and obstetric bleeding to reduce intraoperative bleeding and improve long-term prognosis. The benefit risk ratio in clinical still needs attention.