子痫前期的预防新进展

New progress in prevention of preeclampsia

子痫前期是妊娠期常见的、涉及多系统的功能紊乱性疾病,对孕妇和胎儿都有风险。目前所有预防措施中低剂量阿司匹林的研究最为全面,2019年ACOG指南推荐12周后子痫前期高风险的孕妇服用低剂量阿司匹林作为PE的重要预防措施。WHO推荐钙补充剂作为预防PE的措施之一,特别是在低血钙、饮食钙摄入不足的人群。其他药物、抗氧化剂、钠摄入控制的预防目前证据不足且尚存争议。本文将重点对子痫前期预防的最新指南、研究进展进行综述。

Preeclampsia is a common gestational disease,involves multisystem disorder and carries risks for both mother and baby.Low-dose aspirin is the most comprehensive among the prevention candidates.The 2019 ACOG recommends the use of low-dose aspirin after 12 weeks of gestation as prevention if the patient has one or more of high-risk factors.WHO recommends calcium supplementation as one of strategy for prevention of preeclampsia,especially for the pregnant women who are likely to be low serum calcium or low calcium intake.Other medicines,antioxidants or sodium restriction are lack of evidence even present controversy.This paper highlights the latest guidelines,research findings and other new advances in preeclampsia prevention.