14-3-3ζ蛋白在肝细胞癌发生发展中的作用及研究进展

Role of 14-3-3ζ protein in occurrence and development of hepatocellular carcinoma and the research progress

14-3-3ζ蛋白作为细胞内信号传导过程的主要调控因子,在肝细胞癌(HCC)的发生发展中发挥着重要的作用。多项研究表明,14-3-3ζ蛋白在HCC中表达明显增加,并参与细胞增殖、侵袭及凋亡等多种细胞进程。另外,14-3-3ζ蛋白可通过与多种靶蛋白结合来调节多种信号通路从而促进HCC的发生发展,表明其可能可以作为HCC早期诊断、预后预测、化疗耐药性及治疗的潜在生物学标志物。14-3-3ζ蛋白的过表达,与HCC患者的复发转移风险的增加及生存率降低相关。笔者对14-3-3ζ蛋白在HCC中的表达调控、生物学功能及其对HCC发生发展的影响及相关研究进展作一综述。

14-3-3ζ protein as the central regulatory factor of intracellular signal transduction process plays an important role in the occurrence and development of hepatocellular carcinoma(HCC). Several studies indicated that the expression of 14-3-3ζ protein is elevated significantly in HCC, and participate in various cellular processes such as cell proliferation, invasion, and apoptosis. Additionally, by interacting with a multitude of target proteins, 14-3-3ζ protein can regulate a variety of signaling pathways that contribute to the occurrence and development of HCC, this suggests that it may be used as a potential biomarker for the early diagnosis, prognostic prediction, chemoresistance and treatment of HCC. The overexpression of 14-3-3ζ protein is associated with the increased risk of recurrence and metastasis and the reduced survival rate of HCC patients. The authors review the impact of 14-3-3ζ protein on regulation of expression, biological function and the occurrence and development of HCC and the relevant research progress.