STK25的生物学特性及其与肿瘤关系的研究进展

Biological characteristics of STK25 and its relationship to tumor: recent progress

Ⅲ生发中心激酶(GCK)是一类具有保守的丝/苏氨酸蛋白激酶特征的蛋白激酶家族,与p21活化蛋白激酶(PAK)家族同属于绝育20(Ste20)样激酶家族,参与了广泛的生物学效应,部分成员对外界的刺激可产生相应的应激反应,如细胞增殖、细胞死亡和细胞骨架重排等。STK25作为GCK家族第Ⅲ亚族(GCKⅢ)重要成员之一,参与上述的基本生理过程外,同时在能量代谢、肿瘤的发生与发展中发挥着重要作用。笔者将分别从STK25及家族部分成员的结构特点、分子生物学作用、能量代谢调节及抗肿瘤效应等方面一并进行综述,为最终将其应用于肿瘤的临床治疗提供借鉴。

Germinal center kinases(GCK) are a type of serine/threonine protein kinase characterized by having a conserved serine/threonine protein-kinase domain, and together with p21-activated protein-kinases(PAK), they belong to the sterile twenty(Ste20)-like kinase family, which are involved in a wide variety of physiological processes, and some of them can cause stress responses to external stimuli, such as cell proliferation, apoptosis, skeleton rearrangement. Stk25 as an important member of the subgroup III of the GCK family(GCKIII), in addition to participating in the above-mentioned physiological processes, simultaneously exerts important functions in energy metabolism and the occurrence and development of tumors. Here, the authors address the structural characteristics, biological effects, energy metabolism regulation and anti-tumor effects of STK25, so as to provide a reference for its translation into clinical treatment of tumors.