乌司他丁联合泮托拉唑钠对ICU重症急性胰腺炎患者的疗效及凝血功能、血液流变学的影响

Effect of ulinastatin combined with pantoprazole sodium on coagulation function and hemorheology in patients with severe acute pancreatitis in ICU

目的观察乌司他丁联合泮托拉唑钠对ICU重症急性胰腺炎患者的疗效及凝血功能、血液流变学的影响。方法本研究收集2016年3月一2019年4月在陵水黎族自治县人民医院及海南医学院第一附属医院中心医院重症监护室治疗的重症胰腺炎患者122例作为研究对象,按照随机分组原则,随机分为观察组和对照组,每组患者61例,对照组患者给以泮托拉唑钠治疗,观察组患者给以乌司他丁联合泮托拉唑钠治疗,治疗7 d。比较两组患者的治疗效果、临床指标凝血功能以及血液流变学指标之间的差异。结果经过7d的治疗,观察组患者的总有效率(75.41%)高于对照组(52.46%);发现观察组患者的腹痛缓解时间(1.91±0.88)d、脱离呼吸机时间(3.31±0.37)d、肠道恢复时间(2.61±0.78)d、血液淀粉酶恢复时间(3.33±0.39)d明显小于对照组患者;治疗前两组APTT、PT指标差异无统计学意义(P>0.05)。治疗后两组患者APTT、PT治疗后均明显下降,且研究组患者治疗7d后的APTT.PT明显低于对照组两组差异有统计学意义(P<0.05);两组患者的LRV、HRV以及PV均显著下降,且观察组患者的LRV、HRV以及PV显著低于对照组。结论乌司他丁联合泮托拉唑钠治疗ICU重症急性胰腺炎患者,凝血功能以及血液流变学指标显著改善,疗效较好,建议临床推广。

Objective To observe the ffect of ulinastatin combined with pantoprazole sodium on coagulation function and hemorheology in patients with severe acute pancreatitis in ICU.Methods 122 patients with severe pancreatitis treated in our intensive care unit from March 2016 to April 2019 were randomly divided into observation group and control group according to the principle of random grouping.61 patients in each group were treated with pantoprazole sodium,while 61 patients in control group were treated with ulinastatin.Pantoprazole sodium was given for 7 days.The difference of therapeutie ffect,clinical index,coagulation function and hemorheological index between the two groups were compared.Results After 7 days of treatment,the total eetive rate of paients in the observation group(75.41%)was higher than that in the control group(52.46%);the time of abdominal pain relief in the observation group(1.91±0.88)d,the time of ventilator release(3.31±0.37)d,the time of intestinal tract recovery(2.61±0.78)d,and the time of blood amylase recovery(3.33±0.39)D were significantly smaller than those in the control group.There was no significant difference in APTT and PT between the two groups before treatment(P>0.05).Afer treatment,APTT and PT decreased significantly in both groups,and APTT and PT in the study group were significantly lower than those in the control group 7 days after treatment(P<0.05);LRV,HRV and PV in the two groups were sigificantly decreased,and LRV,HRV and PV in the observation group were significantly lower.Conclusion Ulinastatin combined with pantoprazole sodium in the treatment of severe acute pancreatitis in ICU patients,coagulation function and hemorheological indicators signifcantly improved,the effect is better,and it is recommended that clinical promotion.