低温环境在代谢性疾病防治中的转化应用

Transformation and application of low temperature environment in metabolic disease prevention and treatment

近年来,代谢性疾病的发病率逐年升高,严重影响人体健康和生活质量。因此,深入开展代谢性疾病防治研究工作刻不容缓。低温环境与机体代谢水平密切相关。研究发现低温环境暴露可激活脂肪组织产热代谢,提升机体代谢水平,改善代谢紊乱相关疾病病症。基于低温环境对机体代谢的作用特点和机理,探索并鉴定出低温环境作用途径及靶标,以期为代谢性疾病防治提供新的研究策略和干预手段。本文主要以低温环境暴露介导脂肪产热代谢的三个途径(神经体液信号、免疫细胞途径、脂质代谢物)入手,进行系统概述,并揭示出低温环境在代谢性疾病防治转化应用研究中的价值和意义。

Considering the incidence of metabolic diseases has been increasing in recent years, and seriously affecting human health and quality of life,it is of great urgency to carry out in-depth research on the prevention and treatment of metabolic diseases. The cold environment is closely related to the body metabolic status. Recent studies have shown that exposure to cold environment can increase adipose tissue thermogenesis,enhance the body metabolic rate, and improve metabolic disorders. Based on the characteristics and mechanisms of cold environment on body metabolic status, it is significant to explore and identify the cold environment mediated signaling pathways, and provide new strategies for the prevention and treatment of metabolic diseases.Therefore, this review aims to systematically summarize the three major pathways(neurohumoral signals, immune cell pathways, and lipid metabolites) that mediate adipose thermogenesis by cold environment stimulus,and further reveals the great value and significance of cold environment in the transformation research of metabolic disease prevention and treatment.