血管生成素样蛋白8与冠心病患病及严重程度的相关性

The effect of angiogenin-like protein 8 on the incidence and severity of coronary heart disease

目的观察冠心病(Coronary Heart Disease,CHD)患者血浆血管生成素样蛋白8(Angiogenin-like protein 8,ANGPTL8)水平,评价其与冠状动脉病变程度的相关性。方法选择2018年10月至2019年4月间就诊于我院心内科,并接受冠状动脉造影的患者作为研究对象,冠心病组145例,对照组40例。收集研究对象的一般临床资料,检测受试者血浆ANGPTL8水平以及血脂、血糖等相关指标,采用Gensini评分系统评估冠脉病变严重程度,分析CHD患者ANGPTL8水平与冠脉病变严重程度的相关性。结果冠心病组在空腹血糖(Fasting blood-glucose,FBG)、纤维蛋白原(fibrinogen,FIB)、甘油三酯(Triglyceride,TG)、C反应蛋白(C-reactive protein,CRP)、血浆ANGPTL8浓度等指标水平均高于对照组(均P<0.05),但高密度脂蛋白(High-density lipoprotein,HDL)水平低于对照组(P<0.05);Gensini评分、性别、年龄、糖尿病患病率、TG、CRP等与血浆ANGPTL8浓度呈正相关(P<0.05),HDL与血浆ANGPTL8浓度呈负相关(P<0.05);HDL(β=-0.171,P<0.05)与血浆ANGPTL8浓度(β=-0.645,P<0.05)独立于年龄、性别、FBG等传统危险因素与Gensini评分有线性回归关系。结论CHD患者血清ANGPTL8水平明显升高,且ANGPTL8浓度与冠状动脉病变程度有相关性,对其进行检测能够间接反映CHD患者冠状动脉病变的严重程度。

Objective Plasma levels of angiogenin-like protein 8(ANGPTL8)in patients with coronary heart disease were observed to evaluate its correlation with the degree of coronary artery disease.Methods Patients admitted to the Department of Cardiology of our hospital from October 2018 to April 2019 and received coronary angiography were selected as the study subjects,including 145 patients in the CHD group and 40 patients in the control group.The general clinical data of the subjects were collected,and the plasma ANGPTL8 level,blood lipid,blood glucose and other related indicators were detected.The Gensini scoring system was used to evaluate the severity of coronary artery disease,and the correlation between the ANGPTL8 level and the severity of coronary artery disease in CHD patients was analyzed.Results The levels of FBG,FIB,TG,CRP and plasma ANGPTL8 in the CHD group were all higher than those in the control group(P<0.05),but the HDL level was lower than that in the control group(P<0.05).Gensini score,gender,age,diabetes prevalence,TG and CRP were positively correlated with plasma ANGPTL8 concentration(P<0.05),while HDL was negatively correlated with plasma ANGPTL8 concentration(P<0.05).There was a linear regression relationship between HDL(β=-0.171,P<0.05)and plasma ANGPTL8(β=-0.645,P<0.05),independent of age,gender,FBG and other traditional risk factors and Gensini score.Conclusion Serum levels of ANGPTL8 in CHD patients were significantly increased,and the concentration of ANGPTL8 was correlated with the degree of coronary artery disease.The detection of it could indirectly reflect the severity of coronary artery disease in CHD patients.