急性脊髓损伤血清纤维蛋白原水平与神经功能保留关系的初步探讨

Preliminary Study on Relationship between Serum Fibrinogen Concentrations and Neurological Function Preservation in Acute Spinal Cord Injury

目的初步探讨血清纤维蛋白原水平与急性脊髓损伤神经功能保留的关系。方法选取急性脊髓损伤患者352例为观察组,并按神经功能缺损程度评分标准(NFDS)分为下肢全瘫组(观察A组,258例)及下肢不全瘫组(观察B组,94例);同时选取单纯脊柱骨折无神经损伤患者264例为对照组。比较各组患者入院时外周血血清纤维蛋白原水平。结果观察组血清纤维蛋白原为(3.57±1.35)g·L^-1,对照组为(2.53±1.05)g·L^-1,观察组较对照组显著升高(P<0.05)。观察A组血清纤维蛋白原为(4.23±1.41)g·L^-1,观察B组为(1.05±1.13)g·L^-1,观察A组较观察B组显著升高(P<0.05)。结论血清纤维蛋白原水平可能与急性脊髓损伤患者神经功能保留存在关联。

Objective To explore the relationship between serum fibrinogen levels and nerve function preservation in acute spinal cord injury.Methods A total of 352 patients with acute spinal cord injury(observation group)were divided into complete lower limb paraplegia group(observation group A,n=258)and incomplete lower limb paraplegia group(observation group B,n=94)according to the Neurological Function Defect Scale.In addition,264 spinal fracture patients without nerve injury were selected as the control group.Serum fibrinogen levels were measured on admission.Results Serum fibrinogen concentration in observation group[(3.57±1.35)g·L^-1]was higher than that in control group[(2.53±1.05)g·L^-1],and that in observation group A[(4.23±1.41)g·L^-1]was higher than that in observation group B[(1.05±1.13)g·L^-1](P<0.05).Conclusion Serum fibrinogen levels may be associated with nerve function preservation in patients with acute spinal cord injury.