阿莫西林克拉维酸钾在根除幽门螺杆菌感染中的疗效观察

Effects of amoxicillin and clavulanate potassium in eradicating Helicobacter pylori infection

目的 探讨含阿莫西林克拉维酸钾的四联疗法在根除幽门螺杆菌感染的临床疗效.方法 选取2018年1月-2019年12月在我院体检发现H.pylori阳性就诊于消化内科门诊的患者184例,随机分为观察组96例与对照组88例,观察组给予含阿莫西林克拉维酸钾的四联方案,对照组给予含阿莫西林的四联方案;经治疗14d停药1个月后复查14C-尿素呼气试验.结果 对照组根除率72.7%,观察组根除率88.5%,两组比较,差异有统计学意义(χ^2=7.455,P<0.05);两组不良反应比较,差异有统计学意义(χ^2=5.245,P<0.05).结论 应用含阿莫西林克拉维酸钾的四联疗法治疗H.pylori感染,临床根除疗效及降低不良反应的作用方面优于含阿莫西林的四联疗法,值得临床推广.

Objective To investigate the clinical efficacy of quadruple therapy with amoxicillin and clavulanate potassium in eradicating Helicobacter pylori(Hp) infection. Methods 184 patients who were detected to be Hp positive in gastroenterology clinic of our hospital from January 2018 to December 2019 were randomly divided into the observation group(n=96) and the control group(n=88). The observation group was given amoxicillin and clavulanate potassium for the quadruple therapy, and the control group was given a quadruple therapy containing amoxicillin. The 14C-urea breath test was rechecked after one month of withdrawal followed by 14 days of treatment. Results The eradication rate in the control group was 72.7%, which was lower than 88.5% in the observation group, and the difference was statistically significant(χ2= 7.455, P < 0.05);There was difference in the incidence of adverse reactions between the two groups(χ2=5.245, P < 0.05). Conclusion The application of quadruple therapy with amoxicillin and clavulanate potassium in the treatment of Hp infection is superior to the quadruple therapy with amoxicillin in clinical eradication and reduction of adverse reactions, which is worthy of clinical promotion.