三维可视化辅助下腹腔镜原发性肝癌根治性切除术的效果及对肿瘤标志物指标的影响

The effect of laparoscopic radical resection of primary liver cancer assisted by three-dimensional visualization and its influence on tumor marker indexes

目的 探讨三维可视化辅助下腹腔镜原发性肝癌根治性切除术的效果及对肿瘤标志物指标的影响.方法 选择2016年1月-2019年7月收治的42例原发性肝癌患者作为研究对象,根据手术方案不同分组,对照组21例接受腹腔镜原发性肝癌根治性切除术,观察组21例接受三维可视化辅助下腹腔镜原发性肝癌根治性切除术,对两组手术情况及术后并发症、肿瘤标志物进行比较.结果 观察组术中出血量较对照组低,手术时间、术后肛门排气时间、进食时间较对照组短,差异有统计学意义(P<0.05);观察组术后并发症发生率为4.76%,明显低于对照组28.57%,差异有统计学意义(P<0.05);两组术前的癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原199(CA199)等肿瘤标志物比较,差异无统计学意义(P>0.05),观察组术后7d的上述肿瘤标志物水平明显低于对照组,差异有统计学意义(P<0.05).结论 三维可视化辅助下腹腔镜原发性肝癌根治性切除术可减少手术创伤,缩短术后康复时间,也能降低并发症发生率,减少肿瘤标志物表达,值得推广.

Objective To explore the effect of laparoscopic radical resection of primary liver cancer assisted by three-dimensional visualization and its influence on tumor markers indexes.Methods 42 patients with primary liver cancer admitted from January 2016 to July 2019 were selected as research subjects and were divided into groups according to different surgical plans.21 patients in the control group received laparoscopic radical resection of primary liver cancer and 21 patients in the observation group received laparoscopic radical resection of primary liver cancer assisted by three-dimensional visualization.The operation results,postoperative complications and tumor markers of the two groups were compared.Results The intraoperative blood loss of the observation group was lower than that of the control group,and the operation time,postoperative anal exhaust time and eating time were shorter than those of the control group,with statistically significant difference(P<0.05).The ineidence of postoperative complications in the observation group was 4.76%,which was significantly lower than that in the control group(28.57%),and the difference was statistically significant difference(P<0.05).There was no significant difference in tumor markers such as Carcinoembryonic Antigen(CEA),Alpha-Fetoprotein(AFP),Carbohydrate Antigen 199(CA 199)between the two groups before operation(P>0.05).The level of tumor markers in the observation group 7d after operation was significantly lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Three-dimensional visualization assisted laparoscopic radical resection of primary liver cancer could reduce surgical trauma,shorten postoperative rehabilitation time,lower the incidence of complications and decrease the expression of tumor markers.It is worthy of promotion.