青壮年和老年SARS-COV-2感染患者的临床及影像学特征差异

Comparison of clinical and imaging characteristics between young and elderly patients infected with SARS-COV-2

目的比较青壮年和老年新型冠状病毒(SARS-COV-2)感染患者的临床及影像学特征差异。方法本研究共纳入162例经核酸检测确诊的新型冠状病毒病(COVID-19)患者,根据年龄分为青壮年和老年患者。比较两组患者的临床特征差异,以及影像学特征的差异。结果青壮年和老年患者的临床症状相似,但青壮年患者发热的比例更多(P=0.047),且老年组有更多的重型肺炎患者(P=0.030)。老年患者的C反应蛋白(CPR)水平(P <0.001)、肌红蛋白水平(P=0.005)和D-二聚体水平(P=0.004)较青壮年组显著升高。与青壮年患者相比,在胸部CT上,老年患者的累及的肺叶数目更多(P=0.035),且有更多的在气管边缘分布(P=0.044)。同时,老年患者有更多的有胸腔积液的患者(P=0.031)。结论青壮年和老年(COVID-19)患者表现出略微不同的临床和CT表现。老年患者倾向于具有较轻的临床症状,但受累更多的CT表现。

Objective To compare the clinical and imaging characteristics between young and elderly patients infected with novel coronavirus(SARS-COV-2).Methods A total of 162 patients diagnosed with coronavirus disease 2019(COVID-19)by nucleic acid testing were included and divided into the young group and the elderly group by age.The clinical and imaging characteristics of both groups were compared.Results The young patients and the elderly patients manifested the similar clinical symptoms,with higher proportion of fever cases among the young(P=0.047)and more severe pneumonia cases among the elderly(P=0.030).The levels of C-reactive protein(CRP,P<0.001),myoglobin(P=0.005)and D-dimer(P=0.004)of the elderly patients were significantly higher than that of the young.Compared with the young,the elderly patients had more lung lobes involved on chest CT(P=0.035)with more peribronchial lesions(P=0.044).Moreover,there were more cases of pleural effusion among elderly patients(P=0.031).The clinical and CT findings between young and elderly COVID-19 patients are slightly different.Conclusion The elderly patients present milder clinical symptoms but more involved lung lobes on CT.