MicroRNAs与红系生长发育、增殖、分化及凋亡相关性研究进展

Advances in Research on Relationship between MicroRNAs and Erythroid Growth,Proliferation,Differentiation and Apoptosis

MicroRNA(miRNA)是一种内源性的非编码单链小分子RNA,它是通过与靶基因3'UTR区结合来调控靶基因的表达。miRNA在红细胞生命代谢过程中发挥重要作用,本文意在对miRNA参与调节红系生长发育、增殖、分化及凋亡的机制进行综述。

MicroRNA(miRNA)is endogenously small non-coding regulatory RNA which plays important roles in many critical processes.It regulates gene expression through binding to the untranslated region of target mRNA.MicroRNA acts as a vital part in erythropoiesis.In this review,we mean to summarize the state of knowledge on the role of miRNAs in the regulation of different stages of erythropoiesis.