醒脾养儿颗粒联合孟鲁司特钠治疗小儿牛奶蛋白过敏的临床研究

Clinical study of Xingpi Yanger Granules combined with montelukast sodium in treatment of milk protein allergy in children

目的探讨醒脾养儿颗粒联合孟鲁司特钠对牛奶蛋白过敏患儿的临床疗效。方法选择2017年1月—12月在成都市龙泉驿区妇幼保健院诊治的牛奶蛋白过敏患儿130例作为研究对象,根据随机数字表法分为对照组与观察组,每组各65例。对照组口服孟鲁司特钠咀嚼片,1~4岁患儿4 mg,≥5岁患儿5 mg,临睡前服用,1次/d,持续应用1个月。观察组在对照组治疗的基础上以温水冲服醒脾养儿颗粒,2~4 g/次,1次/d,治疗观察1个月。观察两组患儿的临床疗效,同时比较两组治疗前后的皮肤指数(SI)值、免疫功能指标和炎症因子指标。结果治疗后,观察组治疗的总有效率为96.9%,显著高于对照组的84.6%(P<0.05)。治疗后,两组的牛奶蛋白SI值显著降低(P<0.05);且观察组SI值显著低于对照组(P<0.05)。两组治疗后的免疫球蛋白IgM、IgG与IgA值显著高于治疗前(P<0.05);且观察组IgM、IgG与IgA值显著高于对照组,两组比较差异具有统计学意义(P<0.05)。两组治疗后的血清肿瘤坏死因子-ɑ(TNF-ɑ)、白细胞介素-6(IL-6)水平均显著降低(P<0.05);且治疗后,观察组炎症反应因子水平显著低于对照组,(P<0.05)。结论醒脾养儿颗粒联合孟鲁司特钠在牛奶蛋白过敏患儿中的应用能抑制炎症反应,提高患儿的免疫功能,从而改善患儿的预后。

Objective To investigate the effects of Xingpi Yanger Granules combined with montelukast sodium in treatment of milk protein allergy in children.Methods Children(130 cases)with milk protein allergy in Longquanyi District of Chengdu Maternity and Child Health Care Hospital from January 2017 to December 2017 were selected as subjects,and were equally divided into the control and observation group,each group had 65 cases.Children in the control group were po administered with Montelukast Sodium Chewable Tablets,4 mg for children aged 1—4 years,and 5 mg for children aged more than 5 years,and took them before going to bed once daily.Children in the observation group were po administered with Xingpi Yanger Granules on the basis of control group,2—4 g/time,once daily by warm water.Both groups were treated for 1 month.The clinical efficacy in two groups was observed,and the SI,immune function and inflammatory factors before and after treatment were compared.Results After treatment,the total effective rate of the observation group was 96.9%,significantly higher than 84.6%of the control group(P<0.05).After treatment,SI values in both groups were significantly decreased(P<0.05).And the SI value of the observation group was significantly lower than that of the control group(P<0.05).After treatment,IgM,IgG and IgA in the two groups were significantly higher than those before treatment(P<0.05).After treatment,IgM,IgG,and IgA values of the observation group were significantly higher than those of the control group(P<0.05).After treatment,the levels of TNF-ɑ,IL-6 in two groups were significantly decreased(P<0.05).After treatment,the inflammatory factor level in the observation group was significantly lower than those of the control group(P<0.05).Conclusion The application of Xingpi Yanger Granules combined with montelukast sodium in children with milk protein allergy can inhibit inflammation,improve immune function and improve prognosis of children.