热毒宁注射液联合消旋卡多曲治疗小儿病毒性肠炎的效果观察

Observation of Reduning Injection combined with racecadotril in treatment of viral enteritis in children

目的探讨热毒宁注射液联合消旋卡多曲治疗小儿病毒性肠炎的临床疗效。方法选择2017年12月—2018年12月陕西中医药大学附属医院治疗的120例病毒性肠炎患儿为研究对象。将患儿随机分为对照组和观察组,每组各60例。对照组口服消旋卡多曲颗粒,1.5 mg/kg,3次/d,连续服用3 d。观察组在对照组的基础上静脉滴注热毒宁注射液于100 mL生理盐水中稀释,0.6 mL/(kg·d),1次/d,连续治疗3 d。观察两组患者的临床疗效,同时比较两组治疗前后的临床症状评分和炎性因子水平。结果治疗后,观察组总有效率为96.67%,显著高于对照组的85.00%(P<0.05)。治疗后,两组恶心呕吐、大便异常、腹痛和腹泻评分均显著下降(P<0.05),且观察组各临床症状积分均显著低于对照组(P<0.05)。治疗后,两组患儿白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平均显著下降(P<0.05),且观察组治疗后炎性因子水平显著低于对照组(P<0.05)。结论热毒宁注射液联合消旋卡多曲治疗小儿病毒性肠炎的效果显著,可显著降低患儿的炎性因子水平,具有一定的临床推广价值。

Objective To investigate the effect of Reduning Injection combined with racecadotril in treatment of viral enteritis.Methods Children(120 cases)with viral enteritis in the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from December 2017 to December 2018 were selected as study subjects.Children were randomly divided into control group and observation group with 60 cases in each group.Children in the control group were po administered with Racecadotril Granules,1.5 mg/kg,three times daily.Children in the observation group were iv administered with Reduning Injection on the basis of control group,diluted in 100 mL normal saline,0.6 mL/(kg·d),once daily.Children in two groups were treated consecutively for 3 days.The clinical efficacy in two groups was observed,and the clinical symptom scores and inflammatory factor levels in two groups were compared before and after treatment.Results After treatment,the total effective rate of the observation group was 96.67%,which was significantly higher than 85.00%of the control group(P<0.05).After treatment,scores of nausea and vomiting,abnormal stool,abdominal pain,and diarrhea in two groups were significantly decreased(P<0.05),and scores of clinical symptoms in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of IL-6,CRP and TNF-αin two groups were significantly decreased(P<0.05),and the levels of inflammatory factors in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Reduning Injection combined with racecadotril has a remarkable effect in treatment of viral enteritis in children,and can significantly reduce the level of inflammatory factors in children,it has certain clinical promotion value.