血府逐瘀片对老年2型糖尿病合并慢性阻塞性肺疾病肺功能、氧化应激指标和炎症指标的影响

Effect of Xuefu Zhuyu Tablets on pulmonary function,oxidative stress,and inflammatory factors in elderly patients with T2DM combined with COPD

目的探讨血府逐瘀片对老年2型糖尿病(T2DM)联合慢性阻塞性肺疾病(COPD)患者肺功能、氧化应激指标和炎症指标的影响。方法选择河南省三门峡市中医院自2016年3月—2018年12月收治的老年T2DM合并COPD患者95例作为研究对象,根据入院先后顺序将患者分为对照组(47例)和观察组(48例)。对照组行T2DM及COPD基础治疗,观察组在对照组治疗基础上加用血府逐瘀片,6片/次,2次/d。两组均治疗2个月。对比两组治疗前后的肺功能、氧化应激指标、炎症指标水平及治疗期间的不良反应。结果治疗后,两组的用力肺活量(FVC)、肺活量(VC)、用力呼气容积(FEV1)、最大自主通气量(MVV)、FEV1/FVC水平均明显升高(P<0.05),且观察组肺功能指标水平显著高于对照组(P<0.05)。治疗后,两组的超氧化物歧化酶(SOD)水平均明显上升,且观察组明显高于对照组(P<0.05);两组的丙二醛(MDA)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平明显下降,且观察组明显低于对照组(P<0.05)。观察组的不良反应发生率高于对照组,但组间对比无统计学意义。结论血府逐瘀片可能通过抑制老年T2DM合并COPD患者机体的氧化应激反应,降低炎症反应,从而改善其肺通气功能。

Objective To investigate the effect of Xuefu Zhuyu Tablets on pulmonary function,oxidative stress,and inflammatory factors in elderly patients with T2DM combined with COPD.Methods A total of 95 elderly patients with T2DM combined COPD in Traditional Chinese Medicine Hospital of Sanmenxia City from March 2016 to December 2018 were selected as study subjects,and the patients were divided into control group(47 cases)and observation group(48 cases)according to the order of admission.Patients in the control group was treated with T2DM and COPD basic treatment,and patients in the observation group were po administered with Xuefu Zhuyu Tablets on the basis of the control group,6 tablets/time,twice daily.Both groups were treated for 2 months.After treatment,the pulmonary function,oxidative stress,inflammation,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the levels of FVC,VC,FEV1,MVV,and FEV1/FVC in two groups were significantly increased(P<0.05),and the pulmonary function indexes in the observation group were significantly higher than those in the control group(P<0.05).After treatment,SOD level in two groups was increased significantly,and the observation group was higher than that in the control group(P<0.05).And the levels of MDA,IL-6,and hs-CRP in two groups were significantly decreased,and the indexes in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was higher than that in the control group,but there was no statistically significant difference between two groups.Conclusion Xuefu Zhuyu Tablets may improve pulmonary ventilation function by inhibiting oxidative stress response and reducing inflammation in elderly patients with T2DM combined with COPD.