中老年人群血清唾液酸水平变化与非酒精性脂肪性肝病的关系研究

Association between serum sialic acid levels and nonalcoholic fatty liver disease in middle-aged and elderly population

目的探讨中老年人群血清唾液酸水平变化与非酒精性脂肪性肝病(NAFLD)的相关性。方法选取2014年1月至12月在浙江大学附属第一医院健康管理中心参加健康体检者7610例,回顾性分析这些45岁及以上的中老年健康体检者血清唾液酸水平与NAFLD患病率及患病风险的关系。结果所有受检者NAFLD患病率为44.8%。NAFLD组年龄、男/女、BMI、腹围、收缩压、舒张压、γ-谷氨酰转肽酶、TG、TC、HDL-C、LDL-C、FPG、尿酸和唾液酸水平与对照组比较差异均有统计学意义(均P<0.01)。进一步分析发现,血清唾液酸水平与NAFLD患病率呈正相关,其中血清唾液酸水平在第1、第2、第3和第4个四分位数区间的调查人群NAFLD患病率分别为35.7%、41.6%、47.3%和54.8%(趋势检验P<0.001);多因素logistic回归分析发现,血清唾液酸水平与NAFLD患病风险显著相关(OR=1.385,95%CI:1.074~1.785,P<0.05)。结论血清唾液酸水平变化与中老年人群NAFLD患病率及患病风险存在联系。

Objective To explore the association of serum sialic acid levels with nonalcoholic fatty liver disease(NAFLD)in middle-aged and elderly population.Methods A total of 7610 subjects aged 45 years or older who attended health check-up in the First Affiliated Hospital of Zhejiang University School of Medicine from January to December 2014,were enrolled in the study.The association of serum sialic acid levels with risk of NAFLD was analyzed.Results The overall prevalence of NAFLD was 44.8%in this population,and subjects with NAFLD had higher serum sialic acid levels than the controls(all P<0.01).Serum sialic acid levels was positively correlated with NAFLD prevalence,which was 35.7%in participants with serum sialic acid in the first quartile,and increased to 41.6%,47.3%and 54.8%in the second,third,and fourth quartile groups,respectively(P<0.001 for trend).Multivariate logistic regression analysis showed that serum sialic acid levels was independently associated with an increased risk of NAFLD(OR=1.385,95%CI:1.074~1.785,P<0.05).Conclusion This study indicates that serum sialic acid levels is associated with prevalence and risk of NAFLD in middle-aged and elderly population.