前列地尔联合还原型谷胱甘肽治疗早中期慢性肾衰竭的临床效果观察

Clinical efficacy of alprostadil combined with reduced glutathione in the treatment of early and middle stage chronic renal failure

目的观察前列地尔联合还原型谷胱甘肽治疗早中期慢性肾衰竭的临床效果。方法选取2016年4月-2017年3月济宁市第一人民医院收治的早中期慢性肾衰竭患者58例为研究对象,采取随机数字表法为观察组和对照组,每组29例。在常规饮食干预基础上,对照组给予前列地尔治疗,观察组给予前列地尔联合还原型谷胱甘肽治疗。比较2组到达研究终点存留患者,治疗前及治疗0.5、1、1.5、2年末血红蛋白、肾小球滤过率(e GFR)、24 h尿蛋白水平。结果2组治疗0.5、1年末存留率比较差异无统计学意义(P>0.05),观察组治疗1.5、2年末存留率均高于对照组(P<0.05);治疗1、1.5、2年末,观察组血红蛋白、e GFR、24 h尿蛋白水平均优于对照组(P<0.05)。结论前列地尔联合还原型谷胱甘肽治疗早中期慢性肾衰竭患者效果较好,可有效减轻患者肾脏压力,延缓肾脏功能减退。

Objective To observe the clinical effect of prostaglandin combined with reduced glutathione in the treatment of early and middle stage chronic renal failure.Methods 58 patients with early and middle-term chronic renal failure admitted to Jining First People’s Hospital from April 2016 to March 2017 were selected as the research subjects,and the random number table method was adopted as the observation group and the control group,with 29 cases in each group.On the basis of conventional dietary intervention,the control group was given alprostadil treatment,and the observation group was given alprostadil combined with reduced glutathione treatment.Hemoglobin,glomerular filtration rate(e GFR),and 24 h urine protein levels were compared between the remaining patients who reached the study end point before and after treatment at 0.5,1,1.5,and 2 years.Results There was no significant difference in the survival rate between the two groups at the end of0.5 and 1 year of treatment(P>0.05),and the retention rate of the observation group at the end of 1.5 and 2 years of treatment was higher than that of the control group(P<0.05).At the end of 1,1.5,and 2 years of treatment,the hemoglobin,e GFR,and 24 h urine protein levels in the observation group were better than those in the control group(P<0.05).Conclusion The combination of alprostadil and reduced glutathione in patients with chronic renal failure in the early and middle stages can effectively reduce renal pressure and delay renal dysfunction.