摘要
Background This study aims at characterizing the extent of correlation of treatment response (TR) obtained in various observation settings (home,school,clinic) by different observers (parents,teachers,clinicians).Methods Children with attention deficit hyperactivity disorder (ADHD) underwent a 2-week double-blind,randomized,cross-over clinical trial with methylphenidate and placebo,and various measures were obtained during the 2 weeks.Interrelationships of TR were examined using Pearson's correlation coefficients.Results The study included 526 children (420 male,106 female) with ADHD.TR between different observers shows a variable correlation between parents and teachers.No correlation is seen between parents/teacher evaluation of TR and laboratory-based measures (Continuous Performance Task;Restricted Academic Situation Scale).Conclusion The results firmly support the need to synthesize information from many sources in evaluating TR in ADHD.
基金
VB was supported by a fellowship from CIHR and from McGill University.This work was supported in part by grants from the Fonds de la recherche en sante du Quebec(FRSQ#6690)
the Canadian Institutes of Health Research(MOP#53309,MOP#84537,MOP#126023)to RJ and NG.SMS is a recipient of the 2008 NARSAD Young Investigator and 2009 Dr.Mortimer D.Sackler Developmental Psychology Investigator Awards.
