丁香酚纳米颗粒的制备及其最优化条件

Preparation and Optimization of Eugenol Nanoparticles

为提高丁香酚(EG)的稳定性,采用反溶剂沉淀法,利用玉米醇溶蛋白(zein)包封EG,并加入阿拉伯胶(AG)作为稳定剂,制备载EG的复合纳米颗粒。以包封率为指标,通过响应面分析,对zein与EG质量比、zein与AG质量比、zein质量浓度三个工艺条件进行优化。结果表明:m(zein)∶m(EG)=5.23,m(zein)∶m(AG)=0.23,zein质量浓度为2.63 mg/mL时,包封率最高为59.56%。

To improve the stability of eugenol,we prepared the compound nanoparticles embedding eugenol by reverse-solvent precipitation method where zein was used to encapsulate eugenol and gum arabic was added as stabilizer. With the encapsulation efficiency as the index,three technological parameters were optimized by response surface analysis including the mass ratios of zein to eugenol,zein to gum arabic and the mass concentration of zein. The results show that the maximum encapsulation efficiency is 59.56% at m(zein)∶m(eugenol)of 5.23,m(zein)∶m(gum arabic)of 0.23,in zein mass concentration of 2.63 mg/mL.