糖尿病肾病(DN)患者血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平的变化及其与炎症因子的关系研究

A Study on the Serum Level of Vaspin and its Relationship with the Inflammatory Factors in Patients with Diabetic Nephropathy

目的:分析糖尿病肾病(Diabetic Nephropthy,DN)患者血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平的变化及其与炎症因子的关系。方法:将我院近期(2016年10月-2019年10月)收治100例DN患者设置为DN组,依据DN临床进展分期分组,39例白蛋白尿正常者设置为A组、40例早期DN微量蛋白尿者设置为B组、21例临床DN大量蛋白尿者设为C组,并选取同期于我院的健康体检健康者50例设置为健康组。检测和比价各组糖脂代谢水平、血清Vaspin、炎性因子水平,并进行相关性分析。结果:四组入组者脂代谢各项指标水平相比差异无统计学意义(P>0.05)。而DN组中A组、B组、C组患者血清糖代谢水平均明显高于健康组(P<0.05)。DN组各组Vaspin、TNF-α、IL-6、MCP-1水平均高于健康组(P<0.05)。C组、B组、A组IL-6、TNF-α、MCP-1升高,Vaspin降低(P<0.05)。A组IL-10水平高于健康组(P<0.05)。其余各组间比较(P>0.05)。各组Vaspin水平与促炎因子IL-6、TNF-α、MCP-1水平呈负相关(P<0.05),与抗炎因子IL-10水平无关(P>0.05)。结论:随着疾病的严重程度增加,DN患者血清vaspin呈上升趋势,且与患者的炎症因子呈负相关。检测vaspin水平的变化有助于临床对该病的防治。

Objective: To analyze the changes of serum lipid-specific serine protease inhibitor(Vaspin) levels in patients with diabetic nephropathy(DN) and its relationship with inflammatory factors. Methods: 100 patients with DN who were admitted to our hospital recently(October 2016-October 2019) were set as the DN group, grouped according to the clinical progress of DN, 39 cases of normal albuminuria were set as group A and 40 cases of early DN Microproteinuria patients were set as group B, 21 cases of clinical DN massive proteinuria were set as group C, and 50 healthy subjects who were checked in our hospital during the same period were selected as the healthy group. The glucose and lipid metabolism levels, serum Vaspin, and inflammatory factor levels of each group were detected and compared, and correlation analysis was performed. Results: There was no significant difference in the levels of lipid metabolism among the four groups(P>0.05). The serum glucose metabolism levels of patients in group A, B and C in DN group were significantly higher than those in healthy group(P<0.05). The levels of Vaspin, TNF-α, IL-6 and MCP-1 in the DN group were higher than those in the healthy group(P<0.05). IL-6, TNF-α, MCP-1 increased in group C, B and A, and Vaspin decreased(P<0.05). The level of IL-10 in group A was higher than that in healthy group(P<0.05). Comparison among other groups(P>0.05). Vaspin levels in each group were negatively correlated with the levels of pro-inflammatory factors IL-6, TNF-α, and MCP-1(P<0.05), and were not related to the levels of anti-inflammatory factor IL-10(P>0.05). Conclusion: As the severity of the disease increases, the serum vaspin of patients with DN is on the rise, and it is negatively correlated with the patient’s inflammatory factors. Detection of changes in vaspin levels can help prevent and treat the disease clinically.