CD8+T细胞干细胞样亚群在肿瘤免疫治疗中的应用前景

Application prospect of stem celllike subpopulations of CD8+T cells in tumor immunotherapy

免疫治疗带来一定的临床获益,仍需探索.免疫细胞亚群对于免疫治疗中的肿瘤控制至关重要.CD8+T细胞干细胞样亚群具有自我增殖和向效应细胞分化的潜能从而产生持久的抗肿瘤免疫反应.本文将从免疫检查点抑制剂免疫治疗中免疫细胞应答的机制,分子功能特性,与免疫治疗疗效的相关性以及在肿瘤免疫治疗中的应用策略等方面来阐述CD8+T细胞干细胞样亚群在肿瘤免疫治疗中的应用前景.

Immunotherapy brings certain clinical benefits,but it still needs to be explored.Immune cell subsets are essential for tumor control in immunotherapy.Stem cell-like subpopulations of CD8+T cells own the potential to selfproliferate and differentiate into effector cells so as to produce a prolonged antitumor immune response.Here,we will discuss stem cell-like subpopulations of CD8+T cells with regard to the immune response mechanism of immune checkpoint inhibitor immunotherapy,its molecular and functional characteristics and relationship with immunotherapy efficacy,and its application strategies in tumor immunotherapy.This review will highlight the potential therapeutic implications of inducing or utilizing stem cell-like subpopulations of CD8+T cells for tumor immunotherapy.