530-750nm波长强脉冲光治疗面部日光性黑子的疗效及安全性评价

Evaluation of the efficacy and safety of intense pulsed light treatment for facial solar lentigines withwavelength between 530-750nm

目的 探讨530-750nm波长强脉冲光治疗面部日光性黑子的疗效及安全性.方法 本研究纳入25例面部日光性黑子患者,使用530-750nm波长强脉冲光治疗1次,术后1个月,使用主观评价及客观评价方式来进行疗效评价. 结果 治疗后日光性黑子的改善程度评价:96%(24/25)为卓越(76-100%),4%(1/25)为显效(51-75%).患者VAS评分平均为9.28±0.61.VISIA皮肤检测仪的色斑分值:治疗前为93.93±10.69,治疗后为73.97±8.23,治疗前后比较,差异有统计学意义(t=19.253, P<0.001).无持久性红斑、色素沉着、色素脱失、烫伤/水疱、瘢痕等不良反应.结论 530-750nm波长强脉冲光用于治疗面部日光性黑子,疗效佳、安全性高.

Objective To evaluate the efficacy and safety of intense pulsed light treatment for solar lentigines with wavelength between 530-750nm.Methods This study enrolled twenty-five patients diagnosed as facial solar lentigines.They were treated with intense pulsed light with wavelength between 530-750nm.One month after single treatment,objective and subjective methods were utilized to evaluate the efficacy.Results The 96%(24/25)patients had excellent(76-100%)response,4%(1/25)patients had good response.The average of visual analogue scale was 9.28±0.61.The mean value of pre-and post-treatment of VISIA spot points were 93.93±10.69 and 73.97±8.23.The difference of the points showed a statistically significant improvement(t=19.253,P<0.001).No adverse events(prolonged erythema,hyperpigmentation,hypopigmentation,burn/blister,scar)were observed.Conclusions As to facial solar lentigines,intense pulsed light with wavelength between 530-750nm can achieve excellent results without side effects.