甲泼尼龙联合环磷酰胺治疗系统性红斑狼疮的临床效果及对补体水平的影响

Clinical effect of methylprednisolone combined with cyclophosphamide in the treatment of systemic lupus erythematosus and its influence on complement level

目的探讨甲泼尼龙联合环磷酰胺治疗系统性红斑狼疮的临床效果及对补体水平的影响。方法选取我院2018年1月至2019年12月收治的64例系统性红斑狼疮患者作为研究对象,按照用药方式的不同将其分为观察组(甲泼尼龙联合环磷酰胺)和对照组(甲泼尼龙),各32例。比较两组的治疗效果。结果治疗后,观察组血清IgG、IgM、IgA、CD8^+低于对照组,CD3^+、CD4^+高于对照组(P<0.05)。治疗后,观察组的补体C3、C4水平高于对照组,CRP、IL-6水平低于对照组(P<0.05)。观察组治疗后的SLEDAI评分低于对照组,治疗总有效率高于对照组(P<0.05)。结论甲泼尼龙联合环磷酰胺能有效改善系统性红斑狼疮患者的免疫能力,提高补体水平,减轻炎症反应,值得临床推广和应用。

Objective To investigate the clinical effect of methylprednisolone combined with cyclophosphamide in the treatment of systemic lupus erythematosus and its influence on complement level.Methods Sixty-four patients with systemic lupus erythematosus treated in our hospital from January 2018 to December 2019 were selected as the research objects and divided into observation group(methylprednisolone combined with cyclophosphamide)and control group(methylprednisolone)according to the different medication methods,with 32 cases in each group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of serum IgG,IgM,IgA and CD8^+in the observation group were lower than those in the control group,while CD3^+and CD4^+in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of complement C3 and C4 in the observation group were higher than those in the control group,the levels of CRP and IL-6 were lower than those in the control group(P<0.05).The SLEDAI score of the observation group after treatment was lower than that of the control group,and the total effective rate of treatment was higher than that of the control group(P<0.05).Conclusion Methylprednisolone combined with cyclophosphamide can effectively ameliorate the immune capacity of patients with systemic lupus erythematosus,improve the complement level,and reduce the inflammatory reaction,which is worthy of clinical promotion and application.