血清降钙素原水平在急性缺血性脑卒中患者病情严重程度、预后评估中的临床价值

Clinical value of serum procalcitonin level in evaluation of severity and prognosis of patients with acute ischemic stroke

目的探讨血清降钙素原(PCT)水平在急性缺血性脑卒中(AIS)患者病情严重程度、预后评估中的临床价值。方法选取2016年1月至2019年1月于本院就诊的120例AIS患者为病例组,另选取同期在院体检的40例健康人群为对照组。比较各组研究对象血清PCT水平,并分析病例组并发症及预后情况。结果病例组血清PCT水平明显高于对照组,差异具有统计学意义(P<0.05);中症组、重症组血清PCT水平高于轻症组,且重症组高于中症组,差异具有统计学意义(P<0.05)。治疗1周后,轻症组、中症组、重症组血清PCT水平均较治疗前下降,差异具有统计学意义(P<0.05);治疗1周后,中症组、重症组血清PCT水平明显高于轻症组,且重症组明显高于中症组,差异具有统计学意义(P<0.05)。重症组脑疝、褥疮、肺部感染发生率及死亡率均明显高于轻症组和中症组,差异具有统计学意义(P<0.05);轻症组和中症组脑疝、褥疮、肺部感染发生率及死亡率比较,差异均无统计学意义(P>0.05)。风痰瘀阻证AIS患者血清PCT水平明显高于其他证型(P<0.05)。结论血清PCT水平可用于AIS患者病情及预后评估,尤其对风痰瘀阻证患者有诊断意义。

Objective To investigate the clinical value of serum procalcitonin(PCT)level in evaluation of severity and prognosis of patients with acute ischemic stroke(AIS).Methods A total of 120 AIS patients admitted in our hospital from January 2016 to January 2019 were selected as case group,and 40 healthy people who underwent physical examination in the hospital during the same period were selected as control group.The serum PCT level of each group was compared,and the complications and prognosis of the case group were analyzed.Results The level of serum PCT in the case group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The level of serum PCT in the moderate group and severe group was higher than that in the mild group,and that in the severe group was higher than the moderate group,and the difference was statistically significant(P<0.05).After 1 week of treatment,the levels of serum PCT in the mild group,moderate group and severe group were significantly lower than those before treatment(P<0.05);after 1 week of treatment,the level of serum PCT in the moderate group and severe group was significantly higher than that in the mild group,and that in the severe group was significantly higher than the moderate group(P<0.05).The incidences of cerebral hernia,bedsore and pulmonary infection and mortality in the severe group were significantly higher than those in the mild group and moderate group,and the differences were statistically significant(P<0.05);there were no significant differences in the incidences of cerebral hernia,bedsore and pulmonary infection and mortality between the mild group and moderate group(P>0.05).The level of serum PCT of AIS patients with wind phlegm stasis syndrome was significantly higher than that of other syndrome types,and the difference was statistically significant(P<0.05).Conclusion Serum PCT level can be used to evaluate the condition and prognosis of AIS patients,and it has diagnostic significance for patients with wind phlegm stasis syndrome.