金丝马尾连中1个具有抗病毒活性的异喹啉新生物碱

A new antiviral isoquinoline alkaloid from Thalictrum glandulosissimum

对毛莨科唐松草属植物金丝马尾连的化学成分进行研究。运用硅胶、凝胶、MCI-gel树脂及RP-HPLC等多种色谱技术从金丝马尾连全株95%乙醇提取物中分离鉴定了1个新的异喹啉生物碱类化合物,通过理化性质和波谱数据鉴定该化合物,并命名为1-(6-羟基-7-甲基异喹啉-1-基)乙酮(1)。生物活性测试表明,该化合物对烟草花叶病毒的相对抑制率为28.4%,接近对照宁南霉素的相对抑制率30.2%,具有显著的抗烟草花叶病毒活性。

A new isoquinoline alkaloid(1)has been isolated from the whole plant of Thalictrum glandulosissimum by using various chromatographic techniques,including silica gel,sephadex,MCI-gel resin,and RP-HPLC,and its structure was determined as 1-(6-hydroxy-7-methylisoquinolin-1-yl)ethantone by physicochemical properties and spectroscopic data.This compound was evaluated for anti-tobacco mosaic virus(TMV)activity.The results showed that it had prominent anti-TMV activity with inhibition rates of 28.4%.This rate was closed to that of positive control.