基于新型冠状病毒感染肺炎防疫专利信息共享平台的中药抗病毒专利分析

Analysis of traditional Chinese medicine from patent information sharing platform of coronavirus disease 2019 (COVID-19)

中医药专利能够及时体现该学科最新的科研成果,该研究提取并分析新型冠状病毒感染肺炎防疫专利信息共享平台的中药专利,旨在为新型冠状病毒肺炎的预防和治疗提供证据参考。通过浏览新型冠状病毒感染肺炎防疫专利信息共享平台,筛选和纳入中药抗病毒专利,应用VOSviewer 1.6.14对专利中的中药绘制网络图谱并分析。共纳入292项专利,其中对因治疗专利52个,对症治疗专利240个。结果表明,所有专利共涉及32个省份,以北京、广东、江苏等地为主;发明人共1 076人;共356味中药,71个单味方和221个组方;对因治疗专利主要针对冠状病毒的治疗,而对症治疗专利主要关注发热、咳嗽等呼吸道症状的改善;高频中药共有14味,分别是甘草、黄芩、金银花、连翘、板蓝根、黄芪、薄荷、石膏、鱼腥草、大青叶、大黄、栀子、桔梗、苦杏仁。该研究通过对新型冠状病毒感染肺炎防疫专利信息共享平台中的中药专利进行分析,与《新型冠状病毒肺炎诊疗方案(试行第七版)》吻合度较高,聚类中的药物合用和单味药的研究可为以后提供方向。

Coronavirus disease 2019(COVID-19)is a newly emerged and highly contagious respiratory disease.Traditional Chinese medicine(TCM)has both systematism theory knowledge and clinical practical value in the prevention and treatment of COVID-19.Therefore,it was particularly important to examine the effect of TCM in the prevention and treatment of COVID-19.The patents of TCM might reflect the latest progression of scientific research.We aimed to provide reference for the prevention and treatment of COVID-19 by extracting and analyzing the TCM patents from the Patent Information Sharing Platform of COVID-19.The antiviral TCM patents were screened and exported from the Patent Information Sharing Platform.VOSviewer 1.6.14 was used to visualize and analyze the network of TCM in these patents.There were total 292 TCM patents,including 52 patents for etiological treatment and 240 patents for symptomatic treatment.Thirty-two provinces and 1076 inventors were involved,mainly from Beijing,Guangdong and Jiangsu.Overall,there were 356 TCMs,71 single prescriptions,and 221 compound prescriptions.The patents for treatment of coronavirus mainly focused on the treatment of coronavirus,while the patents for symptomatic treatment mainly focuses on the improvement of respiratory symptoms,such as fever and cough.There were 14 highly frequently used TCMs,including Glycyrrhizae Radix et Rhizoma,Scutellariae Radix,Lonicerae Japonicae Flos,Forsythiae Fructus,Isatidis Radix,Astragali Radix,Menthae Haplocalycis Herba,Gypsum Fibrosum,Houttuyniae Herba,Isatidis Folium,Rhei Radix et Rhizoma,Gardeniae Fructus,Platycodonis Radix,Armeniacae Semen Amarum.The analyzed results of the TCM patents from the patent information sharing platform of COVID-19 were consistent with the Guideline of Diagnosis and Treatment of COVID-19(7th edition),and the combination of TCM in each cluster may also provide future directions for drug compatibility.