多索茶碱联合噻托嗅桉粉雾剂治疗慢性阻塞性肺疾病临床效果观察

Observation on the Effect of Doxofylline Combined with Tiotropine Sputum Powder on Chronic Obstructive Pulmonary Disease

目的:研究多索茶碱联合噻托嗅桉粉雾剂治疗慢性阻塞性肺疾病(简称慢阻肺)临床应用效果。方法:选取收治的800例慢阻肺患者作为本次研究对象,随机将这800例患者分为对照组与观察组,每组400例。对照组给予多索茶碱片治疗,观察组在对照组基础上联合噻托嗅桉粉雾剂治疗。观察两组患者用药后的临床效果和不良反应。结果:在患者用药后的总有效率对比中,观察组患者显著优于对照组,差异有统计学意义(P<0.05);在反映肺功能的用力肺活量(FVC)、第一秒用力呼气量(FEV1)、第一秒用力呼气量与用力肺活量的比值(FEV1/FCC)的对比中,观察组的指标水平也优于对照组,组间差异有统计学意义(P<0.05);两组患者用药后的不良反应对比中,未表现出明显差异,差异无统计学意义(P>0.05)。结论:多索茶碱片与噻托嗅桉粉雾剂联合用药治疗慢阻肺,相较于单药多索茶碱片,其临床疗效显著,总有效率高,对肺功能指标的改善明显,同时联合用药也未增加不良反应,值得临床推广与应用。

Objective To study the clinical application of doxofylline combined with tiotropine sputum powder in the treatment of chronic obstructive pulmonary disease.Method 800 patients with chronic obstructive pulmonary disease admitted to our hospital were enrolled.The 800 patients were randomly divided into control group and observation group,with 400 cases in each group.The control group was treated with doxofylline tablets,and the observation group was treated with tiotropium sputum powder on the basis of the control group.The clinical effects and adverse reactions of the two groups of patients after treatment were observed.Results In the total effective rate after treatment,the patients in the observation group were significantly better than the control group,the difference was statistically significant(P<0.05);the forced vital capacity(FVC)reflecting the lung function,and the forced expiratory volume in the first second(FEV1)In the comparison of forced expiratory volume and forced vital capacity(FEV1/FCC)in the first second,the index level of the observation group was also superior to the control group,and the difference between the groups was significant(P<0.05);In the adverse reaction comparison,the two groups did not show significant difference(P>0.05).Conclusion Doxofylline tablets combined with tiotropine sputum powder for the treatment of COPD,compared with the single drug doxofylline tablets,its clinical efficacy is significant,the total effective rate is high,and the improvement of lung function index is obvious.At the same time,the combination of drugs did not increase the adverse reactions,which is worthy of clinical promotion and application.