慢性阻塞性肺疾病动物模型及评价方法研究进展

Advances in animal models and evaluation methods of chronic obstructive pulmonary disease

慢性阻塞性肺病(COPD)在全球范围都具有较高发病率及致死率,其慢性进展的过程对个人家庭乃至社会医疗资源带来沉重的负担。由于对发病机制的研究仍然不够确切,其创新疗法及新药研发的过程未出现重大突破。建立动物模型对发病机制的了解具有重要意义,对寻找新疗法和治疗靶点提供支持。本文对COPD常用的造模动物及方法做一总结,并阐述理想模型的评价方法。

Chronic obstructive pulmonary disease(COPD)has a high morbidity and mortality rate worldwide,and its chronic progression imposes a heavy burden on individual families and social medical resources.As the research of pathogenesis is still inexact,there is no significant breakthrough in the development of innovative therapies and new drugs.The establishment of animal models can be of great significance for understanding the pathogenesis,and provide support for finding new therapies and therapeutic targets.This paper summarizes the modelling animals and methods commonly used in COPD,and describes the evaluation methods of ideal models.