地特胰岛素在妊娠合并糖尿病治疗中的疗效和安全性评价

Evaluation of the Efficacy and Safety of Insulin Detemir in the Treatment of Pregnancy Complicated with Diabetes

目的 分析地特胰岛素在妊娠合并糖尿病治疗中的临床疗效和安全性,探讨地特胰岛素在妊娠合并糖尿病治疗中的应用价值.方法 抽取2017年7月—2019年7月期间于该院就诊的80例妊娠合并糖尿病患者为该次研究对象,随机将其分为对照组与研究组,每组40例,对照组患者实施生物合成人胰岛素治疗方案,研究组实施地特胰岛素治疗方案,观察两组患者治疗前后血糖水平、不良反应发生情况以及妊娠结局,并对数据进行分析统计.结果 分析后显示,两组患者治疗前空腹血糖、餐后2 h血糖差异无统计学意义(P>0.05),治疗后两组空腹血糖、餐后2 h血糖均有所下降,但研究组明显较低于对照组(P<0.05),研究组不良反应发生率明显低于对照组(P<0.05),且研究组不良妊娠结局发生率低于对照组(P<0.05).结论 针对妊娠期糖尿病患者采用地特胰岛素治疗方案疗效更佳,可有效降低血糖水平,并改善妊娠结局,且具有较高的临床用药安全性.

Objective To analyze the clinical efficacy and safety of insulin detemir in the treatment of pregnancy complicated with diabetes,and to explore the application value of insulin detemir in the treatment of pregnancy complicated with diabetes.Methods From July 2017 to July 2019,80 pregnant patients with diabetes mellitus who were treated in the hospital were selected as the research object.They were randomly divided into a control group and a research group,40 cases in each group.Synthesized human insulin treatment plan,the study group implemented the insulin detemir treatment plan,observed the blood glucose levels,side effects and pregnancy outcomes of the two groups of patients before and after treatment,and analyzed the statistics.Results analysis showed that there was no statistically significant difference in fasting blood glucose before treatment and 2 h postprandial blood glucose between the two groups of patients(P>0.05).After treatment,fasting blood glucose and 2 h postprandial blood glucose decreased in both groups,but the research group was significantly lower than the control group(P<0.05),the incidence of side effects in the study group was significantly lower than that in the control group(P<0.05),and the incidence of adverse pregnancy outcomes in the study group was lower than that in the control group(P<0.05).Conclusion The treatment with insulin detemir for gestational diabetes patients is more effective,can effectively reduce blood glucose levels,improve pregnancy outcomes,and has a higher clinical drug safety.