复方丹参片联合硫酸镁治疗附睾炎的疗效及对病人血清炎性因子水平的影响

Clinical observation of compound salvia tablet combined with magnesium sulfate in the treatment of epididymitis and its effect on the inflammatory factor level in patient serum

目的观察复方丹参片联合硫酸镁治疗附睾炎的临床效果及对血清炎性因子水平的影响。方法附睾炎病人120例,根据随机数字表将病人分成实验组和对照组,每组60例。对照组使用盐酸左氧氟沙星注射液治疗21天。实验组在对照组用药方式的基础上,加用复方丹参片联合硫酸镁湿敷治疗21天,观察两组的疗效和临床症状评分,比较两组病人白细胞介素(IL)-1β、IL-6和肿瘤坏死因子(TNF)-α的水平。结果实验组治疗总有效率为91.67%,高于对照组的80%(P<0.05)。对照组治疗前后疼痛评分分别为(10.57±0.05)和(5.30±0.11),实验组分别为(10.54±0.09)和(3.30±0.02);对照组治疗前后生活质量(QOL)评分分别为(8.33±0.82)和(4.37±0.04),实验组分别为(8.57±0.03)和(3.26±0.03),治疗前后组内比较和治疗后组间比较差异均有统计学意义(P<0.05)。实验组治疗后病人血清IL-1β、IL-6和TNF-α含量分别为(49.92±0.45)pg/ml,(8.94±0.16)pg/ml和(7.10±0.14)pg/ml,对照组分别为(88.31±0.31)pg/ml,(18.25±0.26)pg/ml和(16.06±0.22)pg/ml,治疗后实验组炎性因子水平均较对照组降低(P<0.05)。结论复方丹参片联合硫酸镁湿敷可有效治疗附睾炎,降低血清炎性因子水平。

Objective To observe the clinical effect of compound salvia tablet combined with magnesium sulfate in the treatment of epididymitis and the effect on the inflammatory factor levels in patient serum.Methods 120 cases were randomly divided into experimental group and control group.The control group was observed with levofloxacin hydrochloride injection for 21 days.In the experimental group,on the basis of the medication method of the control group,was treated with compound salvia tablet combined with magnesium sulfate for 21 days.The clinical effect in the experimental group and control group were observed.The levels of inflammatory factors of IL-1β,IL-6 TNF-αand in patient serum of two groups were detected.Results The effective rate 91.67%in the experimental group was obviously higher than that in the control group(80%).Before and after treatment,the pain scores in the control group were 10.57±0.05 and 5.30±0.11;the pain scores in the experimental group were 10.54±0.09 and 3.30±0.02;the QOL scores in the control group were 8.33±0.82 and 4.37±0.04;and the QOL scores in the experimental group were 8.57±0.03 and 3.26±0.03,with statistically significant differences(P<0.05).Compared with the control group,patients’pain scores and QOL in the experimental group were obviously decreased(P<0.05).After treatment,levels of inflammatory factor in the serum of the experimental group were(49.92±0.45)pg/ml,(8.94±0.16)pg/ml and(7.10±0.14)pg/ml,levels of inflammatory factor in the serum of the control group were(88.31±0.31)pg/ml,(18.25±0.26)pg/ml and(16.06±0.22)pg/ml,and the experimental group were better than the control group after treatment(P<0.05).Conclusion Compound salvia tablet combined with magnesium sulfate can effectively treat epididymitis and reduce the level of inflammatory factors in patients’serum.