腹腔镜结直肠癌根治术前患者口服肠内营养剂的价值分析

The Value Analysis of Orally Administering Intestinal Nutrients before Patients Undergoing Laparoscopic Radical Procedure for Colorectal Cancer

为探讨腹腔镜结直肠癌根治术前患者口服肠内营养剂的价值,将于我院行腹腔镜结直肠癌根治术治疗的84例患者随机分为对照组和观察组,各42例,对照组患者术前1周常规饮食,观察组术前1周口服肠内营养剂(瑞素),比较2组患者入院时与术后第3天的免疫指标、营养指标及炎性指标水平,以及术后恢复和并发症发生情况。结果显示,1)免疫及营养指标:与入院时相比,术后第3天观察组患者外周血IgA、IgM、IgG水平及白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HB)水平无明显变化(P>0.05),而对照组各指标水平明显降低(P<0.05);2组术后比较,观察组各指标水平明显高于对照组(P<0.05)。2)炎性指标:与入院时相比,2组术后第3天C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均明显升高(P<0.05),其中对照组升高幅度更大;2组术后第3天比较,观察组CRP、IL-6水平明显低于对照组(P<0.05)。3)术后恢复及并发症发生情况:观察组术后首次肛门排气时间、首次经口进食时间明显短于对照组(P<0.05)。2组术后并发症发生率比较差异无统计学意义(P>0.05)。结果表明,腹腔镜结直肠癌根治术前患者口服肠内营养剂,不仅可改善患者免疫功能及营养状况,而且有助于降低术后炎症反应,促进其恢复,具有积极意义。

This study was to explore the value of orally administering intestinal nutrients(IN)before patients undergoing laparoscopic radical procedure(LRP)for colorectal cancer,randomly divided 84 colorectal cancer patients to be subject to LRP in author’s hospital into control group(42 cases,routine diet 1 week before surgery)and observation group(42 cases,IN 1 week before surgery);then,compared both groups’following items as immunological norms,nutrition norms and the levels of inflammatory norms when admintted and on the 3 rd day after surgery,as well the status on recovery and on complication incidence after surgery.As results,1)immuno-and nutrition norms:compared with that when admitted,in observation group the levels of peripheral blood IgA,IgM and IgG,as well ALB,PA and HB had no significant changes(P>0.05)on the 3 rd after surgery,but in control group above-mentioned indexes were all significantly higher than control group(P<0.05).2)inflammatory norms:compared with that when admitted the levels of CRP,and IL-6 in both groups were significantly uplifted(P<0.05),and control group was more higher to uplift;but on the 3 rd day after surgery the levels of CRP and IL-6 in observation group were significantly lower than that in control group(P<0.05).3)the status on postoperative recovery and complication incidence:in the time of first-time flatus,and of eating through mouth observation group was significantly shorter than control group(P<0.05);in postoperative complication incidence there was no statistical difference between the two groups(P>0.05).Results show that orally administering IN before patients undergoing LRP can not only improve their immunofunction and nutrition status,but is helpful to reduce postoperative inflammatory response,promote patients recovered.