ω-3多不饱和脂肪酸在结直肠癌术后并脓毒症休克患者肠外营养支持中的应用效果分析

Parenteral Nutrition Support Efficacy of ω-3 Poly Unsaturated Fatty Acids on Colorectal Cancer Patients with Postoperative Complication of Septic Shock

为探讨ω-3多不饱和脂肪酸在结直肠癌术后并脓毒症休克患者肠外营养支持中的应用效果,将2014年1月至2019年1月我科诊治的54例结直肠癌术后并脓毒症休克患者随机分为对照组和观察组,各27例,对照组采取常规肠外营养支持,观察组在对照组肠外营养支持基础上加用ω-3多不饱和脂肪酸,比较2组患者治疗前后APACHEⅡ评分、营养状况、炎症因子指标水平,以及ICU住院时间和1个月内病死率。结果显示,2组患者治疗前APACHEⅡ评分、血清总蛋白及白蛋白水平、C-反应蛋白(CRP)、白介素-6(IL-6)水平比较差异均无统计学意义,P>0.05;治疗后,观察组患者APACHEⅡ评分、CRP和IL-6水平均明显低于对照组,观察组患者血清总蛋白及白蛋白水平均明显高于对照组,P<0.05。观察组ICU住院时间明显短于对照组,P<0.05。2组1个月内病死率比较差异无统计学意义,P>0.05。结果表明,对结直肠癌术后并脓毒症休克患者在常规肠外营养支持基础上加用ω-3多不饱和脂肪酸,可改善患者机体营养状况,减轻炎症反应,促进患者康复,值得推荐。

This study was to investigate the parenteral nutrition support(PNS)efficacy ofω-3 poly unsaturated fatty acids(PUFA)on colorectal cancer patients with postoperative complication of septic shock(SS),randomly divided 54 cases met above condition treated in authors’department(2014-01-2019-01)into control group(27 cases,received routine PNS)and observation group(27 cases,routine one plusω-3 PUFA);then,compared both groups’APACHEⅡscore,nutrition status,inflammatory factor’s level before and after treatment,ICU stay,and morbidity within 1 month.As results,before treatment in APACHEⅡscore,serum level of total protein and albumin CRP and IL-6 level,and there was no statistical difference(P>0.05);after treatment in APACHEⅡscore,in CRP and IL-6 level,and in serum levels of total protein and albumin observation group was respectively and significantly lower and higher than control group(P<0.05);Also,in ICU stay shorter than control group(P<0.05);As for the mobidity within one month there was no statistical difference between the two groups(P>0.05).Results show that for the colorectal cancer patients with postoperative complication of SS addingω-3 PUFA can improve their nutrition status,reduce inflammatory response,promote their rehabilitation.It is worthy of popularization.