复合膳食纤维对溃疡性结肠炎患者肠黏膜屏障功能的影响

Influence of Compound Dietary Fiber on Intestinal Mucosal Barrier Function of Ulcerative Colitis Patients

为探讨复合膳食纤维对溃疡性结肠炎(UC)患者肠黏膜屏障功能的影响,将126例UC患者随机分为A、B、C 3组,各42例,3组均常规口服美沙拉秦治疗,除此之外,予以肠内营养干预,A组单纯应用能全素,B组联合应用能全素+膳食纤维[可溶性膳食纤维(SDF)与不溶性膳食纤维(IDF)之比为1∶2],C组联合应用能全素+膳食纤维(SDF∶IDF为1∶3)。比较3组患者外周血D-乳酸水平、二胺氧化酶(DAO)活性水平。结果显示,治疗前,3组患者D-乳酸含量和DAO活性水平比较差异均无统计学意义,P>0.05。治疗后,3组患者D-乳酸含量和DAO活性水平较治疗前均明显下降,P<0.05。治疗后,B组和C组D-乳酸含量和DAO活性水平明显低于A组,P<0.05;而B组与C组之间无明显差异,P>0.05。结果表明,复合膳食纤维进行肠内营养干预可提高UC患者肠黏膜屏障功能,对肠黏膜修复有积极意义。

This study was to investigate the influence of compound dietary fiber(CDF)on intestinal mucosal barrier function(IMBF)of ulcerative colitis(UC)patients,randomly divided 126 cases of UC into group A,B,C,42 cases for each;the three groups all orally administered mesalazine,then intervened them through intraintestinal nutrition:in group A,using nutrison;in group B,nutrison+dietary fiber(SDF/IDF=1∶2);in group C,nutrison+dietary fiber(SDF/IDF=1∶3);then,compared patients’peripheral blood level of D-lactic acid(D-LA),and activity levels of DAO diamine oxidase between the three groups.As results,before treatment above two parameters had no statistical difference between the three groups(P>0.05);after treatment in all groups the two parameter had significantly declined(P<0.05),only in group B and C were more lower than group A(P<0.05),though there was no significant difference between group B and C(P>0.05).Results show that using CDF to intervene intestinal nutrition can enhance patient’s IMBF,which is beneficial to intestinal mucosa repaired.